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dc.contributor.author
Silva, Berenice Anabel  
dc.contributor.author
Ferrari, Carina Cintia  
dc.date.available
2020-03-12T20:14:38Z  
dc.date.issued
2019-04  
dc.identifier.citation
Silva, Berenice Anabel; Ferrari, Carina Cintia; Cortical and meningeal pathology in progressive multiple sclerosis: A new therapeutic target?; Freund & Pettman Publishers; Reviews In The Neurosciences; 30; 3; 4-2019; 221-232  
dc.identifier.issn
0334-1763  
dc.identifier.uri
http://hdl.handle.net/11336/99365  
dc.description.abstract
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that involves an intricate interaction between the central nervous system and the immune system. Nevertheless, its etiology is still unknown. MS exhibits different clinical courses: recurrent episodes with remission periods ('relapsing-remitting') that can evolve to a 'secondary progressive' form or persistent progression from the onset of the disease ('primary progressive'). The discovery of an effective treatment and cure has been hampered due to the pathological and clinical heterogeneity of the disease. Historically, MS has been considered as a disease exclusively of white matter. However, patients with progressive forms of MS present with cortical lesions associated with meningeal inflammation along with physical and cognitive disabilities. The pathogenesis of the cortical lesions has not yet been fully described. Animal models that represent both the cortical and meningeal pathologies will be critical in addressing MS pathogenesis as well as the design of specific treatments. In this review, we will address the state-of-the-art diagnostic and therapeutic alternatives and the development of strategies to discover new therapeutic approaches, especially for the progressive forms.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Freund & Pettman Publishers  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANIMAL MODELS  
dc.subject
COGNITIVE IMPAIRMENT  
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CORTICAL LESIONS  
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THERAPEUTIC AGENTS  
dc.subject.classification
Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Cortical and meningeal pathology in progressive multiple sclerosis: A new therapeutic target?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-03-11T13:04:07Z  
dc.journal.volume
30  
dc.journal.number
3  
dc.journal.pagination
221-232  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Silva, Berenice Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental. Departamento de Investigación; Argentina  
dc.description.fil
Fil: Ferrari, Carina Cintia. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.journal.title
Reviews In The Neurosciences  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.degruyter.com/view/j/revneuro.ahead-of-print/revneuro-2018-0017/revneuro-2018-0017.xml  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/revneuro-2018-0017