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dc.contributor.author
Hayes, Tyrone B.
dc.contributor.author
Anderson, Lloyd L.
dc.contributor.author
Beasley, Val R.
dc.contributor.author
de Solla, Shane R.
dc.contributor.author
Iguchi, Taisen
dc.contributor.author
Ingraham, Holly
dc.contributor.author
Kestemont, Patrick
dc.contributor.author
Kniewald, Jasna
dc.contributor.author
Kniewald, Zlatko
dc.contributor.author
Langlois, Valerie
dc.contributor.author
Luque, Enrique Hugo
dc.contributor.author
McCoy, Krista A.
dc.contributor.author
Muñoz de Toro, Monica Milagros
dc.contributor.author
Oka, Tomohiro
dc.contributor.author
Oliveira, Cleida A
dc.contributor.author
Orton, Frances
dc.contributor.author
Ruby, Sylvia
dc.contributor.author
Suzawa, Miyuki
dc.contributor.author
Tavera Mendoza, Luz E.
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Trudeau, Vance L.
dc.contributor.author
Victor Costa, Anna Bolivar
dc.contributor.author
Willingham, Emily
dc.date.available
2020-02-12T19:42:23Z
dc.date.issued
2011-10
dc.identifier.citation
Hayes, Tyrone B.; Anderson, Lloyd L.; Beasley, Val R.; de Solla, Shane R.; Iguchi, Taisen; et al.; Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes; Pergamon-Elsevier Science Ltd; Journal of Steroid Biochemistry and Molecular Biology; 127; 1-2; 10-2011; 64-73
dc.identifier.issn
0960-0760
dc.identifier.uri
http://hdl.handle.net/11336/97329
dc.description.abstract
Atrazine is the most commonly detected pesticide contaminant of ground water, surface water, and precipitation. Atrazine is also an endocrine disruptor that, among other effects, alters male reproductive tissues when animals are exposed during development. Here, we apply the nine so-called "Hill criteria" (Strength, Consistency, Specificity, Temporality, Biological Gradient, Plausibility, Coherence, Experiment, and Analogy) for establishing cause-effect relationships to examine the evidence for atrazine as an endocrine disruptor that demasculinizes and feminizes the gonads of male vertebrates. We present experimental evidence that the effects of atrazine on male development are consistent across all vertebrate classes examined and we present a state of the art summary of the mechanisms by which atrazine acts as an endocrine disruptor to produce these effects. Atrazine demasculinizes male gonads producing testicular lesions associated with reduced germ cell numbers in teleost fish, amphibians, reptiles, and mammals, and induces partial and/or complete feminization in fish, amphibians, and reptiles. These effects are strong (statistically significant), consistent across vertebrate classes, and specific. Reductions in androgen levels and the induction of estrogen synthesis - demonstrated in fish, amphibians, reptiles, and mammals - represent plausible and coherent mechanisms that explain these effects. Biological gradients are observed in several of the cited studies, although threshold doses and patterns vary among species. Given that the effects on the male gonads described in all of these experimental studies occurred only after atrazine exposure, temporality is also met here. Thus the case for atrazine as an endocrine disruptor that demasculinizes and feminizes male vertebrates meets all nine of the "Hill criteria".
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ATRAZINE
dc.subject
ENDOCRINE DISRUPTOR
dc.subject
GONADS
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-01-29T19:20:38Z
dc.journal.volume
127
dc.journal.number
1-2
dc.journal.pagination
64-73
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Hayes, Tyrone B.. University of California; Estados Unidos
dc.description.fil
Fil: Anderson, Lloyd L.. University of Iowa; Estados Unidos
dc.description.fil
Fil: Beasley, Val R.. University of Illinois at Urbana; Estados Unidos
dc.description.fil
Fil: de Solla, Shane R.. Wildlife and Landscape Science Directorate; Canadá
dc.description.fil
Fil: Iguchi, Taisen. National Institute for Basic Biology; Japón
dc.description.fil
Fil: Ingraham, Holly. University of California; Estados Unidos
dc.description.fil
Fil: Kestemont, Patrick. Université de Namur; Bélgica
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Fil: Kniewald, Jasna. University of Zagreb; Croacia
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Fil: Kniewald, Zlatko. University of Zagreb; Croacia
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Fil: Langlois, Valerie. Royal Military College; Canadá
dc.description.fil
Fil: Luque, Enrique Hugo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: McCoy, Krista A.. University of South Florida; Estados Unidos
dc.description.fil
Fil: Muñoz de Toro, Monica Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Fisiología. Laboratorio de Endocrinología y Tumores Hormonodependientes; Argentina
dc.description.fil
Fil: Oka, Tomohiro. IDEA Consultants; Japón
dc.description.fil
Fil: Oliveira, Cleida A. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Orton, Frances. Colegio Universitario de Londres; Reino Unido
dc.description.fil
Fil: Ruby, Sylvia. Concordia University; Canadá
dc.description.fil
Fil: Suzawa, Miyuki. University of California; Estados Unidos
dc.description.fil
Fil: Tavera Mendoza, Luz E.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Trudeau, Vance L.. University of Ottawa; Canadá
dc.description.fil
Fil: Victor Costa, Anna Bolivar. Universidade Federal de Minas Gerais; Brasil
dc.description.fil
Fil: Willingham, Emily. No especifica;
dc.journal.title
Journal of Steroid Biochemistry and Molecular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jsbmb.2011.03.015
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960076011000665
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