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dc.contributor.author
Matta, M.
dc.contributor.author
Pavy Le Traon, Anne
dc.contributor.author
Pérez Lloret, Santiago
dc.contributor.author
Laporte, C.
dc.contributor.author
Berdugo, I.
dc.contributor.author
Nasr, N.
dc.contributor.author
Hanaire, H.
dc.contributor.author
Senard, J. M.
dc.date.available
2020-02-10T15:35:43Z
dc.date.issued
2018-03
dc.identifier.citation
Matta, M.; Pavy Le Traon, Anne; Pérez Lloret, Santiago; Laporte, C.; Berdugo, I.; et al.; Predictors of cardiovascular autonomic neuropathy onset and progression in a cohort of type 1 diabetic patients; Hindawi Publishing Corporation; Journal of Diabetes Research; 2018; 3-2018; 1-8; 5601351
dc.identifier.issn
2314-6745
dc.identifier.uri
http://hdl.handle.net/11336/97056
dc.description.abstract
Aim. The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. Methods. 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years. CAN staging was achieved according to the Toronto Consensus Panel on Diabetic Autonomic Neuropathy into 4 categories: absent, possible, confirmed, or severe CAN. Results. Out of the 175 patients included, 31.4% were free of CAN, 34.2% had possible CAN, 24.6% had confirmed CAN, and 9.7% exhibited severe CAN at the first assessment. Among the 103 patients with nonsevere CAN at inclusion, forty-one (39.8%) had an increase of at least one category when reassessed and 62 (60.2%) remained stable. A bivariate analysis indicated that only BMI and exposure to selective serotonin reuptake inhibitors (SSRIs) were significantly different in both groups. A multivariate analysis indicated that lower BMI (OR: 0.15, CI 95%: 0.05-0.48, p = 0 003) and SSRI exposure (OR: 4.18, CI 95%: 1.03-16.97, p = 0 04) were the sole predictors of CAN deterioration. In the 55 patients negative for CAN at the first laboratory assessment, 12 became positive at the second assessment. Conclusion. No clear predictive factor for CAN onset was identified. However, once present, CAN progression was related to low BMI and SSRI exposure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
autonomic neuropathy
dc.subject
diabetes
dc.subject
progression
dc.subject
predictors
dc.subject.classification
Endocrinología y Metabolismo
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Predictors of cardiovascular autonomic neuropathy onset and progression in a cohort of type 1 diabetic patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T14:40:53Z
dc.journal.volume
2018
dc.journal.pagination
1-8; 5601351
dc.journal.pais
Egipto
dc.journal.ciudad
El Cairo
dc.description.fil
Fil: Matta, M.. Centre Hospitalier Universitaire de Toulouse; Francia
dc.description.fil
Fil: Pavy Le Traon, Anne. Institut des Maladies Métaboliques et Cardiovasculaires; Francia. Hôpital Pierre-Paul Riquet; Francia
dc.description.fil
Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Laporte, C.. Centre Hospitalier Universitaire de Toulouse; Francia
dc.description.fil
Fil: Berdugo, I.. Centre Hospitalier Universitaire de Toulouse; Francia
dc.description.fil
Fil: Nasr, N.. Hôpital Pierre-Paul Riquet; Francia. Institut des Maladies Métaboliques et Cardiovasculaires; Francia
dc.description.fil
Fil: Hanaire, H.. Centre Hospitalier Universitaire de Toulouse; Francia
dc.description.fil
Fil: Senard, J. M.. Centre Hospitalier Universitaire de Toulouse; Francia. Institut des Maladies Métaboliques et Cardiovasculaires; Francia
dc.journal.title
Journal of Diabetes Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jdr/2018/5601351/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2018/5601351
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