Artículo
Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus
De S.F. Tischer, Paula Cristina; Talarico, Laura Beatriz
; Noseda, Miguel D.; Pita B. Guimarães, Silvia Maria; Damonte, Elsa Beatriz
; Duarte, Maria Eugênia R.
Fecha de publicación:
03/2006
Editorial:
Elsevier
Revista:
Carbohydrate Polymers
ISSN:
0144-8617
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Chemical and spectroscopic methods showed that the major KCl-precipitated galactans from Meristiella gelidium (Solieriaceae) are iota/kappa/nu-hybrid carrageenans with the former one in higher proportion. These carrageenans showed, by HPSEC-MALLS analysis, unimodal symmetrical peaks with MW of 425.6–956.7 kDa. The effectiveness of the crude extracts from M. gelidium against HSV-2 was higher than the corresponding extract from G. griffithsiae, previously determined. However, when considering the homogeneous carrageenans, the fractions obtained from both seaweeds showed the same level of activity. The extracts and carrageenan derived from M. gelidium were more effective inhibitors of DENV-2 if compared with G. griffithsiae samples and reference polysaccharides. The most active fraction obtained from M. gelidium showed a selectivity index against HSV-2 of 25,000, a value high enough to consider this carrageenan as a promising agent to be evaluated for the treatment of genital HSV-2 infections.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
De S.F. Tischer, Paula Cristina; Talarico, Laura Beatriz; Noseda, Miguel D.; Pita B. Guimarães, Silvia Maria; Damonte, Elsa Beatriz; et al.; Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus; Elsevier; Carbohydrate Polymers; 63; 4; 3-2006; 459-465
Compartir
Altmétricas