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dc.contributor.author
Haro, Ana Cecilia
dc.contributor.author
Monaco, Maria Eugenia
dc.contributor.author
Medina, Marcela Susana
dc.date.available
2019-12-03T20:36:21Z
dc.date.issued
2018-01
dc.identifier.citation
Haro, Ana Cecilia; Monaco, Maria Eugenia; Medina, Marcela Susana; Lactobacillus casei beneficially modulates immuno-coagulative response in an endotoxemia model; Lippincott Williams; Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.; 29; 1; 1-2018; 104-110
dc.identifier.issn
0957-5235
dc.identifier.uri
http://hdl.handle.net/11336/91279
dc.description.abstract
The current study aims at evaluating the effect of the oral administration of Lactobacillus casei CERELA (CRL) 431 on parameters implicated in inflammation-coagulation interaction using a model of acute inflammation induced by lipopolysaccharide (LPS) in mice. Six-week-old Balb/c mice were treated with L. casei for 5 consecutive days. Then treated and untreated mice received an LPS injection (L. caseiRLPS and LPS groups, respectively). Liver and kidney were removed, blood samples were obtained, and hemostatic and inflammatory parameters were evaluated at different times post LPS injection. Preventive L. casei administration induced a significant decrease in proinflammatory TNF-A and IL-6 cytokines by decreasing tissue factor expression in liver and kidney. Moreover, the lower expression of tissue factor in the L. caseiRLPS group led to a lower activation of the coagulation system, which was observed by the fast systemic restoration of factors VII and V coagulation factors and antithrombin levels. This study highlights the capacity of L. casei to modulate the hemostatic unbalance in an acute endotoxemia model. Our findings showed the ability of L. casei CRL 431 to regulate the immuno-coagulative response. This fact could be helpful to propose new adjunctive strategies addressed to the restoration of physiological anticoagulant mechanisms in sepsis patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INFLAMMATION-COAGULATION
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MICE ENDOTOXEMIA MODEL
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PROBIOTIC
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SEPSIS
dc.subject.classification
Otras Ciencias de la Salud
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lactobacillus casei beneficially modulates immuno-coagulative response in an endotoxemia model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-22T15:53:09Z
dc.identifier.eissn
1473-5733
dc.journal.volume
29
dc.journal.number
1
dc.journal.pagination
104-110
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Filadelfia
dc.description.fil
Fil: Haro, Ana Cecilia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Aplicada; Argentina
dc.description.fil
Fil: Monaco, Maria Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Aplicada; Argentina
dc.description.fil
Fil: Medina, Marcela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina
dc.journal.title
Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MBC.0000000000000684
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00001721-201801000-00016


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