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dc.contributor.author
Haro, Ana Cecilia  
dc.contributor.author
Monaco, Maria Eugenia  
dc.contributor.author
Medina, Marcela Susana  
dc.date.available
2019-12-03T20:36:21Z  
dc.date.issued
2018-01  
dc.identifier.citation
Haro, Ana Cecilia; Monaco, Maria Eugenia; Medina, Marcela Susana; Lactobacillus casei beneficially modulates immuno-coagulative response in an endotoxemia model; Lippincott Williams; Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.; 29; 1; 1-2018; 104-110  
dc.identifier.issn
0957-5235  
dc.identifier.uri
http://hdl.handle.net/11336/91279  
dc.description.abstract
The current study aims at evaluating the effect of the oral administration of Lactobacillus casei CERELA (CRL) 431 on parameters implicated in inflammation-coagulation interaction using a model of acute inflammation induced by lipopolysaccharide (LPS) in mice. Six-week-old Balb/c mice were treated with L. casei for 5 consecutive days. Then treated and untreated mice received an LPS injection (L. caseiRLPS and LPS groups, respectively). Liver and kidney were removed, blood samples were obtained, and hemostatic and inflammatory parameters were evaluated at different times post LPS injection. Preventive L. casei administration induced a significant decrease in proinflammatory TNF-A and IL-6 cytokines by decreasing tissue factor expression in liver and kidney. Moreover, the lower expression of tissue factor in the L. caseiRLPS group led to a lower activation of the coagulation system, which was observed by the fast systemic restoration of factors VII and V coagulation factors and antithrombin levels. This study highlights the capacity of L. casei to modulate the hemostatic unbalance in an acute endotoxemia model. Our findings showed the ability of L. casei CRL 431 to regulate the immuno-coagulative response. This fact could be helpful to propose new adjunctive strategies addressed to the restoration of physiological anticoagulant mechanisms in sepsis patients.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Lippincott Williams  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
INFLAMMATION-COAGULATION  
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MICE ENDOTOXEMIA MODEL  
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PROBIOTIC  
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SEPSIS  
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Otras Ciencias de la Salud  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Lactobacillus casei beneficially modulates immuno-coagulative response in an endotoxemia model  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-22T15:53:09Z  
dc.identifier.eissn
1473-5733  
dc.journal.volume
29  
dc.journal.number
1  
dc.journal.pagination
104-110  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Filadelfia  
dc.description.fil
Fil: Haro, Ana Cecilia. Universidad Nacional de Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Biotecnología Farmacéutica y Alimentaria; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Aplicada; Argentina  
dc.description.fil
Fil: Monaco, Maria Eugenia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Aplicada; Argentina  
dc.description.fil
Fil: Medina, Marcela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología; Argentina  
dc.journal.title
Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1097/MBC.0000000000000684  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00001721-201801000-00016