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dc.contributor.author
Medina, Jorge Horacio  
dc.date.available
2019-11-08T18:44:08Z  
dc.date.issued
2018-02  
dc.identifier.citation
Medina, Jorge Horacio; Neural, cellular and molecular mechanisms of active forgetting; Frontiers Media SA; Frontiers in Systems Neuroscience; 12; 3; 2-2018; 1-10  
dc.identifier.issn
1662-5102  
dc.identifier.uri
http://hdl.handle.net/11336/88376  
dc.description.abstract
The neurobiology of memory formation attracts much attention in the last five decades. Conversely, the rules that govern and the mechanisms underlying forgetting are less understood. In addition to retroactive interference, retrieval-induced forgetting and passive decay of time, it has been recently demonstrated that the nervous system has a diversity of active and inherent processes involved in forgetting. In Drosophila, some operate mainly at an early stage of memory formation and involves dopamine (DA) neurons, specific postsynaptic DA receptor subtypes, Rac1 activation and induces rapid active forgetting. In mammals, others regulate forgetting and persistence of seemingly consolidated memories and implicate the activity of DA receptor subtypes and AMPA receptors in the hippocampus (HP) and related structures to activate parallel signaling pathways controlling active time-dependent forgetting. Most of them may involve plastic changes in synaptic and extrasynaptic receptors including specific removal of GluA2 AMPA receptors. Forgetting at longer timescales might also include changes in adult neurogenesis in the dentate gyrus (DG) of the HP. Therefore, based on relevance or value considerations neuronal circuits may regulate in a time-dependent manner what is formed, stored, and maintained and what is forgotten.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media SA  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
AMPA RECEPTORS  
dc.subject
BDNF  
dc.subject
DOPAMINE  
dc.subject
DROSOPHILA  
dc.subject
FORGETTING  
dc.subject
HIPPOCAMPUS  
dc.subject
MEMORY  
dc.subject
RAC 1  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Neural, cellular and molecular mechanisms of active forgetting  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-23T14:41:09Z  
dc.identifier.eissn
1662-5137  
dc.journal.volume
12  
dc.journal.number
3  
dc.journal.pagination
1-10  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina  
dc.journal.title
Frontiers in Systems Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fnsys.2018.00003/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnsys.2018.00003