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dc.contributor.author
Inzaugarat, Maria Eugenia
dc.contributor.author
Billordo, Luis Ariel
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Vodánovich, F.
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Cervini Bohm, Gabriela Marta
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Casavalle, Patricia Lucía
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Vedire, C.
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Cherñavsky, Alejandra Claudia
dc.date.available
2016-11-30T18:31:11Z
dc.date.issued
2013-07
dc.identifier.citation
Inzaugarat, Maria Eugenia; Billordo, Luis Ariel; Vodánovich, F.; Cervini Bohm, Gabriela Marta ; Casavalle, Patricia Lucía; et al.; Alterations in innate and adaptive immune leukocytes are involved in paediatric obesity; Wiley; Pediatric Obesity; 9; 5; 7-2013; 381-390
dc.identifier.issn
2047-6310
dc.identifier.uri
http://hdl.handle.net/11336/8522
dc.description.abstract
Background: Adipose tissue is the main source of the cytokines and adipokines that are increased in the context of obesity. The production of reactive oxygen species (ROS) and cytokines by circulating immune cells can be regulated by these pro-inflammatory factors even before infiltration into adipose tissue. Objective: To investigate the alterations that can occur in circulating monocytes and lymphocytes in paediatric obesity. Methods: In this study, 54 paediatric obese patients and 30 age-matched metabolically healthy individuals were enrolled. Intracellular cytokines were analyzed after phorbol myristate acetate (PMA) or leptin plus PMA stimulation of lymphocytes and monocytes by flow cytometry. ROS generation was measured using dichlorofluorescein-diacetate. Both a 'stimulation index' and a 'fold of increase' were calculated for statistical purposes. Results: Both interferon gamma (IFN-γ) production by circulating CD4+ and CD8+ lymphocytes and ROS production by monocytes following PMA stimulation were increased in obese patients. Leptin induced an increased production of IFN-γ in both subsets of T cells and tumour necrosis factor alpha in monocytes, and linoleic acid induced a higher ROS production in monocytes. Conclusions: The distinct functional responses of circulating cells suggest that alterations in both innate and adaptive immune cells are involved in the maintenance of low-grade inflammation in paediatric obesity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MONOCYTES
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OXIDATIVE STRESS
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T CELLS
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TH1/TH2 CYTOKINES
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Alterations in innate and adaptive immune leukocytes are involved in paediatric obesity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-24T17:22:22Z
dc.journal.volume
9
dc.journal.number
5
dc.journal.pagination
381-390
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Inzaugarat, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Billordo, Luis Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Vodánovich, F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Cervini Bohm, Gabriela Marta . Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Casavalle, Patricia Lucía. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Vedire, C.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Cherñavsky, Alejandra Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.journal.title
Pediatric Obesity
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.2047-6310.2013.00179.x/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.2047-6310.2013.00179.x
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