Mostrar el registro sencillo del ítem

dc.contributor.author
Di Rosso, María Emilia  
dc.contributor.author
Palumbo, María Laura  
dc.contributor.author
Genaro, Ana Maria  
dc.date.available
2019-08-30T19:58:03Z  
dc.date.issued
2016-07  
dc.identifier.citation
Di Rosso, María Emilia; Palumbo, María Laura; Genaro, Ana Maria; Immunomodulatory effects of fluoxetine: A new potential pharmacological action for a classic antidepressant drug?; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 109; 7-2016; 101-107  
dc.identifier.issn
1043-6618  
dc.identifier.uri
http://hdl.handle.net/11336/82660  
dc.description.abstract
Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine is usually chosen for the treatment of the symptoms of depression, obsessive-compulsive, panic attack and bulimia nervosa. Antidepressant therapy has been associated with immune dysfunction. However, there is contradictory evidence about the effect of fluoxetine on the immune system. Experimental findings indicate that lymphocytes express the serotonin transporter. Moreover it has been shown that fluoxetine is able to modulate the immune function through a serotonin-dependent pathway and through a novel independent mechanism. In addition, several studies have shown that fluoxetine can alter tumor cell viability. Thus, it was recently demonstrated in vivo that chronic fluoxetine treatment inhibits tumor growth by increasing antitumor T-cell activity. Here we briefly review some of the literature referring to how fluoxetine is able to modify, for better or worse, the functionality of the immune system. These results of our analysis point to the relevance of the novel pharmacological action of this drug as an immunomodulator helping to treat several pathologies in which immune deficiency and/or deregulation is present.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press Ltd - Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Antidepressant  
dc.subject
Fluoxetine  
dc.subject
Immune System  
dc.subject
Immunomodulation  
dc.subject
Serotonin  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Immunomodulatory effects of fluoxetine: A new potential pharmacological action for a classic antidepressant drug?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-08-30T14:16:57Z  
dc.journal.volume
109  
dc.journal.pagination
101-107  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Di Rosso, María Emilia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina  
dc.description.fil
Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina  
dc.description.fil
Fil: Genaro, Ana Maria. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina  
dc.journal.title
Pharmacological Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phrs.2015.11.021  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043661815002790