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dc.contributor.author
Tsukida, Kohichiro
dc.contributor.author
Takahashi, Takuya
dc.contributor.author
Iida, Hikaru
dc.contributor.author
Kanmani, Paulraj
dc.contributor.author
Suda, Yoshihito
dc.contributor.author
Nochi, Tomonori
dc.contributor.author
Ohwada, Shuichi
dc.contributor.author
Aso, Hisashi
dc.contributor.author
Ohkawara, Sou
dc.contributor.author
Makino, Seiya
dc.contributor.author
Kano, Hiroshi
dc.contributor.author
Saito, Tadao
dc.contributor.author
Villena, Julio Cesar
dc.contributor.author
Kitazawa, Haruki
dc.date.available
2019-07-24T20:03:09Z
dc.date.issued
2016-06-24
dc.identifier.citation
Tsukida, Kohichiro; Takahashi, Takuya; Iida, Hikaru; Kanmani, Paulraj; Suda, Yoshihito; et al.; Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells; BioMed Central; BMC Immunology; 17; 21; 24-6-2016; 1-12
dc.identifier.issn
1471-2172
dc.identifier.uri
http://hdl.handle.net/11336/80202
dc.description.abstract
Background: Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer?s patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-like receptor (TLR)-4 activation. Objective: In view of the important role played by phagocytosis in the activation of antigen presenting cells (APCs), the aim of the present work was to examine the interaction of TL2937 with porcine PPMPs focusing on phagocytosis. In addition, this study aimed to investigate whether the effects of L. jensenii TL2937 in porcine blood monocyte-derived dendritic cells (MoDCs) are similar to those found in PPMPs considering that MoDCs do not recapitulate all functions of mucosal APCs. Results: studies showed a high ability of porcine CD172a+ PPMPs to phagocytose L. jensenii TL2937. Interestingly, our results also revealed a reduced capacity of the non-immunomodulatory L. plantarum TL2766 to be phagocytosed by those immune cells. Phagocytosis of L. jensenii TL2937 by porcine PPMPs was partially dependent on TLR2. In addition, we demonstrated that TL2937 strain was able to improve the expression of IL-1, IL-12 and IL-10 in immature MoDCs resembling the effect of this immunobiotic bacterium on PPMPs. Moreover, similarly to PPMPs those immunomodulatory effects were related to the higher capacity of TL2937 to be phagocytosed by immature MoDCs. Conclusions: Microbial recognition in APCs could be effectively mediated through ligand-receptor interactions that then mediate phagocytosis and signaling. For the immunobiotic strain TL2937, TLR2 has a partial role for its interaction with porcine APCs and it is necessary to investigate the role of other receptors. A challenge for future research will be advance in the full understanding of the molecular interactions of immunobiotic L. jensenii TL2937 with porcine APCs that will be crucial for the successful development of functional feeds for the porcine host. This study is a step in that direction.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lactobacillus Jensenii Tl2937
dc.subject
Porcine Antigen Presenting Cells
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Phagocytosis
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Immunobiotics
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Blood Monocytes-Derived Dentritic Cells
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-06-03T14:36:05Z
dc.identifier.eissn
1471-2172
dc.journal.volume
17
dc.journal.number
21
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Tsukida, Kohichiro. Tohoku University; Japón
dc.description.fil
Fil: Takahashi, Takuya. Tohoku University; Japón
dc.description.fil
Fil: Iida, Hikaru. Tohoku University; Japón
dc.description.fil
Fil: Kanmani, Paulraj. Tohoku University; Japón
dc.description.fil
Fil: Suda, Yoshihito. Miyagi University; Japón
dc.description.fil
Fil: Nochi, Tomonori. Tohoku University; Japón
dc.description.fil
Fil: Ohwada, Shuichi. Tohoku University; Japón
dc.description.fil
Fil: Aso, Hisashi. Tohoku University; Japón
dc.description.fil
Fil: Ohkawara, Sou. Meiji Seika Pharma Co., Ltd. Agricultural & Veterinary Division; Japón
dc.description.fil
Fil: Makino, Seiya. Meiji Co., Ltd. Division of Research and Development; Japón
dc.description.fil
Fil: Kano, Hiroshi. Meiji Co., Ltd. Division of Research and Development; Japón
dc.description.fil
Fil: Saito, Tadao. Tohoku University; Japón
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.journal.title
BMC Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1186/s12865-016-0160-1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-016-0160-1
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