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dc.contributor.author
Rudolph, Tanja K.
dc.contributor.author
Rudolph, Volker
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Edreira, Martin Miguel
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Cole, Marsha P.
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Bonacci, Gustavo Roberto
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Schopfer, Francisco J.
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Woodcock, Steven R.
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Franek, Andreas
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Pekarova, Michaela
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Khoo, Nicholas K. H.
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Hasty, Alyssa H.
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Baldus, Stephan
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Freeman, Bruce A.
dc.date.available
2019-07-15T21:03:55Z
dc.date.issued
2010-05
dc.identifier.citation
Rudolph, Tanja K.; Rudolph, Volker; Edreira, Martin Miguel; Cole, Marsha P.; Bonacci, Gustavo Roberto; et al.; Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 30; 5; 5-2010; 938-945
dc.identifier.issn
1079-5642
dc.identifier.uri
http://hdl.handle.net/11336/79596
dc.description.abstract
Objective-: Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide-and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.Methods and results-: Herein, we demonstrate that subcutaneously administered 9-and 10-nitro-octadecenoic acid (nitro-oleic acid) potently reduced atherosclerotic lesion formation in apolipoprotein E-deficient mice. Nitro-fatty acids did not modulate serum lipoprotein profiles. Immunostaining and gene expression analyses revealed that nitro-oleic acid attenuated lesion formation by suppressing tissue oxidant generation, inhibiting adhesion molecule expression, and decreasing vessel wall infiltration of inflammatory cells. In addition, nitro-oleic acid reduced foam cell formation by attenuating oxidized low-density lipoprotein-induced phosphorylation of signal transducer and activator of transcription-1, a transcription factor linked to foam cell formation in atherosclerotic plaques. Atherosclerotic lesions of nitro-oleic acid-treated animals also showed an increased content of collagen and α-smooth muscle actin, suggesting conferral of higher plaque stability. Conclusion-: These results reveal the antiatherogenic actions of electrophilic nitro-fatty acids in a murine model of atherosclerosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Atherosclerosis
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Electrophile
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Foam Cells
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Inflammation
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Nitro-Fatty Acids
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Oxidative Stress
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Enfermedades Vasculares Periféricas
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-07-10T19:06:20Z
dc.journal.volume
30
dc.journal.number
5
dc.journal.pagination
938-945
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Rudolph, Tanja K.. University of Pittsburgh; Estados Unidos. University Heart Center Hamburg; Alemania
dc.description.fil
Fil: Rudolph, Volker. University of Pittsburgh; Estados Unidos. University Heart Center Hamburg; Alemania
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Fil: Edreira, Martin Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Pittsburgh; Estados Unidos
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Fil: Cole, Marsha P.. University of Pittsburgh; Estados Unidos
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Fil: Bonacci, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Pittsburgh; Estados Unidos
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Fil: Schopfer, Francisco J.. University of Pittsburgh; Estados Unidos
dc.description.fil
Fil: Woodcock, Steven R.. University of Pittsburgh; Estados Unidos
dc.description.fil
Fil: Franek, Andreas. University Heart Center Hamburg; Alemania
dc.description.fil
Fil: Pekarova, Michaela. Biology Centre of the Academy of Sciences of the Czech Republic; República Checa
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Fil: Khoo, Nicholas K. H.. University of Pittsburgh; Estados Unidos
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Fil: Hasty, Alyssa H.. Vanderbilt University Medical Center; Estados Unidos
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Fil: Baldus, Stephan. University Heart Center Hamburg; Alemania
dc.description.fil
Fil: Freeman, Bruce A.. University of Pittsburgh; Estados Unidos
dc.journal.title
Arteriosclerosis, Thrombosis, and Vascular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.201582
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1161/ATVBAHA.109.201582
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