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dc.contributor.author
Rudolph, Tanja K.  
dc.contributor.author
Rudolph, Volker  
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Edreira, Martin Miguel  
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Cole, Marsha P.  
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Bonacci, Gustavo Roberto  
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Schopfer, Francisco J.  
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Woodcock, Steven R.  
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Franek, Andreas  
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Pekarova, Michaela  
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Khoo, Nicholas K. H.  
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Hasty, Alyssa H.  
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Baldus, Stephan  
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Freeman, Bruce A.  
dc.date.available
2019-07-15T21:03:55Z  
dc.date.issued
2010-05  
dc.identifier.citation
Rudolph, Tanja K.; Rudolph, Volker; Edreira, Martin Miguel; Cole, Marsha P.; Bonacci, Gustavo Roberto; et al.; Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 30; 5; 5-2010; 938-945  
dc.identifier.issn
1079-5642  
dc.identifier.uri
http://hdl.handle.net/11336/79596  
dc.description.abstract
Objective-: Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide-and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.Methods and results-: Herein, we demonstrate that subcutaneously administered 9-and 10-nitro-octadecenoic acid (nitro-oleic acid) potently reduced atherosclerotic lesion formation in apolipoprotein E-deficient mice. Nitro-fatty acids did not modulate serum lipoprotein profiles. Immunostaining and gene expression analyses revealed that nitro-oleic acid attenuated lesion formation by suppressing tissue oxidant generation, inhibiting adhesion molecule expression, and decreasing vessel wall infiltration of inflammatory cells. In addition, nitro-oleic acid reduced foam cell formation by attenuating oxidized low-density lipoprotein-induced phosphorylation of signal transducer and activator of transcription-1, a transcription factor linked to foam cell formation in atherosclerotic plaques. Atherosclerotic lesions of nitro-oleic acid-treated animals also showed an increased content of collagen and α-smooth muscle actin, suggesting conferral of higher plaque stability. Conclusion-: These results reveal the antiatherogenic actions of electrophilic nitro-fatty acids in a murine model of atherosclerosis.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Lippincott Williams  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Atherosclerosis  
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Electrophile  
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Foam Cells  
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Inflammation  
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Nitro-Fatty Acids  
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Oxidative Stress  
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Enfermedades Vasculares Periféricas  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-07-10T19:06:20Z  
dc.journal.volume
30  
dc.journal.number
5  
dc.journal.pagination
938-945  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Philadelphia  
dc.description.fil
Fil: Rudolph, Tanja K.. University of Pittsburgh; Estados Unidos. University Heart Center Hamburg; Alemania  
dc.description.fil
Fil: Rudolph, Volker. University of Pittsburgh; Estados Unidos. University Heart Center Hamburg; Alemania  
dc.description.fil
Fil: Edreira, Martin Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Pittsburgh; Estados Unidos  
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Fil: Cole, Marsha P.. University of Pittsburgh; Estados Unidos  
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Fil: Bonacci, Gustavo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Pittsburgh; Estados Unidos  
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Fil: Schopfer, Francisco J.. University of Pittsburgh; Estados Unidos  
dc.description.fil
Fil: Woodcock, Steven R.. University of Pittsburgh; Estados Unidos  
dc.description.fil
Fil: Franek, Andreas. University Heart Center Hamburg; Alemania  
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Fil: Pekarova, Michaela. Biology Centre of the Academy of Sciences of the Czech Republic; República Checa  
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Fil: Khoo, Nicholas K. H.. University of Pittsburgh; Estados Unidos  
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Fil: Hasty, Alyssa H.. Vanderbilt University Medical Center; Estados Unidos  
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Fil: Baldus, Stephan. University Heart Center Hamburg; Alemania  
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Fil: Freeman, Bruce A.. University of Pittsburgh; Estados Unidos  
dc.journal.title
Arteriosclerosis, Thrombosis, and Vascular Biology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.201582  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1161/ATVBAHA.109.201582