Artículo
Autophagy and Toxins: A Matter of Life or Death
Fecha de publicación:
12/2012
Editorial:
Bentham Science Publishers
Revista:
Current Molecular Medicine
ISSN:
1566-5240
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Bacterial protein toxins are important virulence factors. A particular class of toxins, the pore-form toxins (PFTs), shares the toxigenic mechanism of forming pores in the membrane of target cells. The relationship between autophagy and bacterial PFTs has been described for several toxin-secreting pathogens and in this review we have recapitulated the more recent findings on this issue. A common outcome is that the target cell, by a yet non-completely defined mechanism, senses the toxin attack and builds up complex responses as a protective mechanism for host survival. However, in some cases, this cellular response is beneficial to the microorganism by supplying an intracellular niche or by promoting host-cell death, which facilitates pathogen spreading.
Palabras clave:
Autophagy
,
Intracellular Patoghens
,
Lc3
,
Pore-Forming Toxins
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - SAN JUAN)
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos de CENTRO CIENTIFICO TECNOLOGICO CONICET - SAN JUAN
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Citación
Mestre Gimenez, Maria Belen; Colombo, Maria Isabel; Autophagy and Toxins: A Matter of Life or Death; Bentham Science Publishers; Current Molecular Medicine; 13; 2; 12-2012; 241-251
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