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dc.contributor.author
Castilla Lozano, Maria del Rocio
dc.contributor.author
Cao, Gabriel Fernando
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Kolliker Frers, Rodolfo Alberto
dc.contributor.author
Muller, Angelica del Carmen
dc.contributor.author
Ambrosio, Giuseppe
dc.contributor.author
Milei, Jose
dc.date.available
2016-10-28T22:25:11Z
dc.date.issued
2014-08
dc.identifier.citation
Castilla Lozano, Maria del Rocio; Cao, Gabriel Fernando; Kolliker Frers, Rodolfo Alberto; Muller, Angelica del Carmen; Ambrosio, Giuseppe; et al.; Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?; Elsevier; International Journal Of Cardiology; 177; 2; 8-2014; 548-550
dc.identifier.issn
0167-5273
dc.identifier.uri
http://hdl.handle.net/11336/7869
dc.description.abstract
Congenital heart diseases (CHD) or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. The proliferation of intimal smooth muscle cells (SMCs), which causes intimal thickenings prior to any evidence of visible lipid deposition, was proposed to be the initial lesion of coronary atherosclerosis. The increasing trend to consider intimal thickenings as possible pre-atherosclerotic lesions is based on the distribution of intimal hyperplasia in children and the localization of characteristic atherosclerotic lesions observed in adult humans. Early coronary artery lesions may range from focal areas with mild myointimal thickenings in prenatal life to early soft plaques in infants, which may also present as intermingled lesions with components of both categories, more frequently observed with increasing age. Also,we proposed that TGF-β1 expressionmight be considered another possible predisposing factor to develop atherosclerotic coronary artery disease in CHD patients. On the other hand, estrogen receptor-α (ERα) appears to be responsible for the protective effects of estrogens against atherosclerotic vascular disease. The aim of this paper was to analyze the immunohistochemical expression of ERα, TGF-β1 and apolipoprotein B in coronary intimal hyperplasia in children with CHD and the possible increased risk for the development pre-atherosclerotic lesions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Coronary Intimal Hyperplasia
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Congenital Heart Disease
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Er Alpha
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Apo B
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Atherogenesis
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-08-30T17:11:39Z
dc.journal.volume
177
dc.journal.number
2
dc.journal.pagination
548-550
dc.journal.pais
Irlanda
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Castilla Lozano, Maria del Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.description.fil
Fil: Ambrosio, Giuseppe. Universita Di Perugia; Italia
dc.description.fil
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
dc.journal.title
International Journal Of Cardiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0167527314016453
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijcard.2014.08.100
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.internationaljournalofcardiology.com/article/S0167-5273(14)01645-3/abstract
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