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dc.contributor.author
Farez, Mauricio Franco
dc.contributor.author
Mascanfroni, Ivan Darío
dc.contributor.author
Mendez Huergo, Santiago Patricio
dc.contributor.author
Yeste, Ada
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Murugaiyan, Gopal
dc.contributor.author
Garo, Lucien P.
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Balbuena Aguirre, María E.
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Patel, Bonny
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Ysrraelit, María C.
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Zhu, Chen
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Kuchroo, Vjay K.
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Quintana, Francisco
dc.contributor.author
Correale, Jorge
dc.date.available
2016-10-19T18:59:32Z
dc.date.issued
2015-09-10
dc.identifier.citation
Farez, Mauricio Franco; Mascanfroni, Ivan Darío; Mendez Huergo, Santiago Patricio; Yeste, Ada; Murugaiyan, Gopal; et al.; Melatonin contributes to the seasonality of multiple sclerosis relapses; Cell Press; Cell; 162; 6; 10-9-2015; 1338-1352
dc.identifier.issn
0092-8674
dc.identifier.uri
http://hdl.handle.net/11336/7741
dc.description.abstract
Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations suggest that environmental factors influence the disease course. Here, we report that melatonin levels, whose production is modulated by seasonal variations in night length, negatively correlate with multiple sclerosis activity in humans. Treatment with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly interferes with the differentiation of human and mouse T cells. Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-α. These results suggest that melatonin is another example of how environmental-driven cues can impact T cell differentiation and have implications for autoimmune disorders such as multiple sclerosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Melatonin
dc.subject
Multiple Sclerosis
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Autoimmunity
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Cell Differentiation
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Encephalomyelitis Autoimmune Experimental
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Melatonin contributes to the seasonality of multiple sclerosis relapses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-10-04T19:27:10Z
dc.identifier.eissn
1097-4172
dc.journal.volume
162
dc.journal.number
6
dc.journal.pagination
1338-1352
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Farez, Mauricio Franco. Fundacion para la Lucha contra las Enfermedades Neurologicas Infancia. Instituto de Investigaciones Neurologicas "Raul Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mascanfroni, Ivan Darío. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Yeste, Ada. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Murugaiyan, Gopal. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Garo, Lucien P.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Balbuena Aguirre, María E.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Fundacion para la Lucha contra las Enfermedades Neurologicas Infancia. Instituto de Investigaciones Neurologicas "Raul Carrea"; Argentina
dc.description.fil
Fil: Patel, Bonny. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Ysrraelit, María C.. Fundacion para la Lucha contra las Enfermedades Neurologicas Infancia. Instituto de Investigaciones Neurologicas "Raul Carrea"; Argentina
dc.description.fil
Fil: Zhu, Chen. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Kuchroo, Vjay K.. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Quintana, Francisco. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Correale, Jorge. Fundacion para la Lucha contra las Enfermedades Neurologicas Infancia. Instituto de Investigaciones Neurologicas "Raul Carrea"; Argentina
dc.journal.title
Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cell.2015.08.025
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570563/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/abstract/S0092-8674(15)01038-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0092867415010387
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