Mostrar el registro sencillo del ítem

dc.contributor.author
Camarini, Rosana  
dc.contributor.author
Pautassi, Ricardo Marcos  
dc.date.available
2019-05-20T17:51:37Z  
dc.date.issued
2016-07  
dc.identifier.citation
Camarini, Rosana; Pautassi, Ricardo Marcos; Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 125; 7-2016; 53-78  
dc.identifier.issn
0361-9230  
dc.identifier.uri
http://hdl.handle.net/11336/76715  
dc.description.abstract
Ethanol-induced behavioral sensitization (EBS) was first described in 1980, approximately 10 years after the phenomenon was described for psychostimulants. Ethanol acts on γ-aminobutyric acid (GABA) and glutamate receptors as an allosteric agonist and antagonist, respectively, but it also affects many other molecular targets. The multiplicity of factors involved in the behavioral and neurochemical effects of ethanol and the ensuing complexity may explain much of the apparent disparate results, found across different labs, regarding ethanol-induced behavioral sensitization. Although the mesocorticolimbic dopamine system plays an important role in EBS, we provide evidence of the involvement of other neurotransmitter systems, mainly the glutamatergic, GABAergic, and opioidergic systems. This review also analyses the neural underpinnings (e.g., induction of cellular transcription factors such as cyclic adenosine monophosphate response element binding protein and growth factors, such as the brain-derived neurotrophic factor) and other factors that influence the phenomenon, including age, sex, dose, and protocols of drug administration. One of the reasons that make EBS an attractive phenomenon is the assumption, firmly based on empirical evidence, that EBS and addiction-related processes have common molecular and neural basis. Therefore, EBS has been used as a model of addiction processes. We discuss the association between different measures of ethanol-induced reward and EBS. Parallels between the pharmacological basis of EBS and acute motor effects of ethanol are also discussed.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Behavioral Sensitization  
dc.subject
Ethanol  
dc.subject
Motor Stimulant Effect  
dc.subject.classification
Salud Ocupacional  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-04-15T18:14:42Z  
dc.journal.volume
125  
dc.journal.pagination
53-78  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Camarini, Rosana. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil  
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.journal.title
Brain Research Bulletin  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0361923016300806?np=y  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.brainresbull.2016.04.006