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dc.contributor.author
Gumilar, Fernanda Andrea
dc.contributor.author
Lencinas, Ileana
dc.contributor.author
Bras, Cristina Liliana
dc.contributor.author
Giannuzzi, Leda
dc.contributor.author
Minetti, Alejandra
dc.date.available
2016-09-09T19:27:33Z
dc.date.issued
2015-02
dc.identifier.citation
Gumilar, Fernanda Andrea; Lencinas, Ileana; Bras, Cristina Liliana; Giannuzzi, Leda; Minetti, Alejandra; Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation; Elsevier; Neurotoxicology And Teratology.; 49; 2-2015; 1-9
dc.identifier.issn
0892-0362
dc.identifier.uri
http://hdl.handle.net/11336/7590
dc.description.abstract
Abstract Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Arsenic
dc.subject
Development Exposure
dc.subject
Sensory-Motor Reflexes
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Functional Observational Battery
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Locomotor Activity
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Rat
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Biología del Desarrollo
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-05-10T14:37:44Z
dc.journal.volume
49
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Lencinas, Ileana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.description.fil
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); Argentina
dc.description.fil
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
dc.journal.title
Neurotoxicology And Teratology.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0892036215000136
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ntt.2015.02.005
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