Artículo
Single-step procedure for trace element determination in synovial fluid by dynamic reaction cell-inductively coupled plasma mass spectrometry
Moyano, Mario Franco
; Verni, Ernesto Ricardo
; Tamashiro, Héctor; Di Genaro, Maria Silvia
; Martinez, Luis Dante
; Gil, Raul Andres
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![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
02/2014
Editorial:
Elsevier
Revista:
Microchemical Journal
ISSN:
0026-265X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A fast and single-step procedure for the dissolution of human synovial fluid in formic acid and further determination by dynamic reaction cell-inductively coupled plasma mass spectrometry (DRC-ICPMS) with a high-efficiency sample introduction system was developed. The samples were collected, treated and analyzed in the same screwcapped tubes. In order to overcome the effect of considerable carbon content, the sample introduction, nebulization and ICP operating conditions were carefully optimized. Furthermore, DRC technology with CH4 as reaction gas was used for the elimination of spectral interferences due to polyatomic ions. The effect of the sample matrix was evaluated and mitigated through comparison of direct calibration against aqueous standards, direct calibration in formic acid media and analyte addition calibration. The recommended procedure involved low dilution and low detection limits (from0.003 μg L−1 for U to 13.3 μg L−1 for Ti) with adequate precision (from 0.6% for Co to 6.6% for Ti). The proposedmethodwas successfully applied to determine 16 trace elements in concentrations from 0.03 μg L−1 (Cd) to 88.2 μg L−1 (Cu) in human synovial fluid samples.
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Identificadores
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Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos(INQUISAL)
Articulos de INST. DE QUIMICA DE SAN LUIS
Articulos de INST. DE QUIMICA DE SAN LUIS
Citación
Moyano, Mario Franco; Verni, Ernesto Ricardo; Tamashiro, Héctor; Di Genaro, Maria Silvia; Martinez, Luis Dante; et al.; Single-step procedure for trace element determination in synovial fluid by dynamic reaction cell-inductively coupled plasma mass spectrometry; Elsevier; Microchemical Journal; 112; 2-2014; 17-24
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