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dc.contributor.author
Rossetti, María Florencia
dc.contributor.author
Cambiasso, Maria Julia
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Holschbach, A.
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Cabrera Kreiker, Ricardo Jorge
dc.date.available
2019-04-23T17:39:46Z
dc.date.issued
2016-07
dc.identifier.citation
Rossetti, María Florencia; Cambiasso, Maria Julia; Holschbach, A.; Cabrera Kreiker, Ricardo Jorge; Oestrogens and Progestagens: Synthesis and Action in the Brain; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 28; 7; 7-2016; 1-27
dc.identifier.issn
0953-8194
dc.identifier.uri
http://hdl.handle.net/11336/74807
dc.description.abstract
When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural tissues, they are more specifically referred to as neurosteroids. These neurosteroids bind specific receptors to promote essential brain functions. Pregnenolone supports cognition and protects mouse hippocampal cells against glutamate and amyloid peptide-induced cell death. Progesterone promotes myelination, spinogenesis, synaptogenesis, neuronal survival and dendritic growth. Allopregnanolone increases hippocampal neurogenesis, neuronal survival and cognitive functions. Oestrogens, such as oestradiol, regulate synaptic plasticity, reproductive behaviour, aggressive behaviour and learning. In addition, neurosteroids are neuroprotective in animal models of Alzheimer's disease, Parkinson's disease, brain injury and ageing. Using in situ hybridisation and/or immunohistochemistry, steroidogenic enzymes, including cytochrome P450 side-chain cleavage, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase, cytochrome P450arom, steroid 5α-reductase and 3α-hydroxysteroid dehydrogenase, have been detected in numerous brain regions, including the hippocampus, hypothalamus and cerebral cortex. In the present review, we summarise some of the studies related to the synthesis and function of oestrogens and progestagens in the central nervous system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Brain
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Neurosteroidogenic Enzymes
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Oestrogen
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Progestagen
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Oestrogens and Progestagens: Synthesis and Action in the Brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-04-15T18:14:08Z
dc.journal.volume
28
dc.journal.number
7
dc.journal.pagination
1-27
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.conicet.avisoEditorial
This is the peer reviewed version of the following article: Rossetti, M. F., Cambiasso, M. J., Holschbach, M. A. and Cabrera, R. (2016), Oestrogens and Progestagens: Synthesis and Action in the Brain. J Neuroendocrinol, 28:. doi:10.1111/jne.12402, which has been published in final form at https://doi.org/10.1111/jne.12402 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.description.fil
Fil: Rossetti, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.description.fil
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Holschbach, A.. State University of Colorado - Fort Collins; Estados Unidos
dc.description.fil
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Journal of Neuroendocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12402
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jne.12402


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