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dc.contributor.author
Bédard, Andréanne
dc.contributor.author
Tremblay, Pierrot
dc.contributor.author
Chernomoretz, Ariel
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dc.contributor.author
Vallières, Luc
dc.date.available
2019-02-21T14:30:22Z
dc.date.issued
2007-06
dc.identifier.citation
Bédard, Andréanne; Tremblay, Pierrot; Chernomoretz, Ariel; Vallières, Luc; Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation; Wiley-liss, Div John Wiley & Sons Inc; Glia; 55; 8; 6-2007; 777-789
dc.identifier.issn
0894-1491
dc.identifier.uri
http://hdl.handle.net/11336/70606
dc.description.abstract
Microglia, monocytes, and peripheral macrophages share a common origin and many characteristics, but what distinguishes them from each other at the level of gene expression remains largely unknown. In this study, we compared the transcriptional profiles of freshly purified microglia, monocytes, and spleen macrophages using Affymetrix Mouse Genome arrays to identify genes predominantly expressed by microglia. Among tens of thousands of genes assayed, 127 potential candidates were found, including nine newly discovered genes encoding plasma membrane and extracellular proteins. In the brain, the latter were selectively expressed by microglia, as revealed by in situ hybridization. Three of them were confirmed to be exclusively (MSR2) or predominantly (GPR12, GPR34) expressed in the brain compared to the other tissues examined. Furthermore, all of these genes were upregulated in activated microglia after treatment with the demyelinating toxin cuprizone, suggesting that they play roles in neuroinflammation. In conclusion, this study reports the identification of new selective markers for microglia, which should prove useful not only to identify and isolate these cells, but also to better understand their distinctive properties. © 2007 Wiley-Liss, Inc.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cuprizone
dc.subject
Demyelination
dc.subject
Dna Microarray
dc.subject
G Protein-Coupled Receptor
dc.subject
Gene Profiling
dc.subject
Microglia
dc.subject
Monocytes
dc.subject
Spleen Macrophages
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-02-12T17:25:10Z
dc.journal.volume
55
dc.journal.number
8
dc.journal.pagination
777-789
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Bédard, Andréanne. Laval University; Canadá
dc.description.fil
Fil: Tremblay, Pierrot. Laval University; Canadá
dc.description.fil
Fil: Chernomoretz, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laval University; Canadá
dc.description.fil
Fil: Vallières, Luc. Laval University; Canadá
dc.journal.title
Glia
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1002/glia.20477
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.20477
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