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dc.contributor.author
Sookoian, Silvia Cristina
dc.contributor.author
Pirola, Carlos José
dc.date.available
2019-01-04T16:40:05Z
dc.date.issued
2012-07
dc.identifier.citation
Sookoian, Silvia Cristina; Pirola, Carlos José; DNA methylation and hepatic insulin resistance and steatosis; Lippincott Williams; Current Opinion In Clinical Nutrition And Metabolic Care; 15; 4; 7-2012; 350-356
dc.identifier.issn
1363-1950
dc.identifier.uri
http://hdl.handle.net/11336/67419
dc.description.abstract
Purpose of review: In this review, we show novel evidence about the role of the liver in the development of insulin resistance and suggest that abnormal hepatic triglyceride accumulation is not an innocent bystander comorbidity but adversely affects the peripheral insulin sensitivity. Recent findings: The core of this review is built up around the concept that liver DNA methylation of the peroxisome proliferative activated receptor gamma coactivator one alpha gene promoter modulates the status of peripheral insulin resistance and is strongly associated with plasma fasting insulin levels. We discuss about other mechanisms associated with peroxisome proliferative activated receptor gamma coactivator one alpha regulation, such as an acetylation and deacetylation switch and how these events impact on the liver metabolic function. We suggest a mitochondrial-centric approach to understand the connection between nonalcoholic fatty liver disease and insulin resistance. We finally show new data about how the liver epigenome is modulated by nutritional cues and introduce the role of epigenetics in liver metabolic programming. Summary: The implications of these findings for clinical practice are promising, as the inherent plasticity of epigenetic modifications, produced either physiologically or pathologically, suggests that early therapeutic intervention in patients with fatty liver can potentially revert the systemic phenotype associated with insulin resistance. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Lippincott Williams
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Acetylation
dc.subject
Deacetylation
dc.subject
Dna Methylation
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Epigenetics
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Fatty Liver
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Histones
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Mitochondria
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Nonalcoholic Steatohepatitis
dc.subject
Pgc1a
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Ppargc1a
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
DNA methylation and hepatic insulin resistance and steatosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-01-02T19:41:53Z
dc.journal.volume
15
dc.journal.number
4
dc.journal.pagination
350-356
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Philadelphia
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Current Opinion In Clinical Nutrition And Metabolic Care
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1097/MCO.0b013e3283546f9f
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info:eu-repo/semantics/altIdentifier/url/https://ovidsp.tx.ovid.com/sp-3.32.0a/ovidweb.cgi?QS2=434f4e1a73d37e8c27e134f44f8715f157d7c2f3ff09b492d600c66adb95764d9d75602d54fb516dbc0d1c2f0a17bcf2d2f2f9096b92ecb13681b7644d6418ae267da1af0dcdb9b7c541868445aefc68268800bf46b4c59b5b7cca83dafccff430210ce6b580af1aa0cdac2d47b3c8ccd03df949a9e3eaf9700bc3109abe3896feb1ae73e1842f4b462c3b10dffc1f1baa912fceaaf552069bc84970a7863c5b6b9022bec1b831005bcce62016a86d7735adcc76f1d5fecab417a236f9fa6fbc20e7b0eef2297a80d76245109ecf0bdbf6f5d7cd5216217349febc7a67fc28f7afa9bb341e3c2e6c7db668a743112036e635422d120c14ebe81e32352ee2a88a93e2dcdd37e3b1bafec2e23e1d1449a7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/co-clinicalnutrition/pages/articleviewer.aspx?year=2012&issue=07000&article=00006&type=abstract
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