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dc.contributor.author
Acosta , Helena  
dc.contributor.author
Lopez, Silvia Liliana  
dc.contributor.author
Revinski, Diego Raul  
dc.contributor.author
Carrasco, Andres Eduardo  
dc.date.available
2019-01-02T21:55:18Z  
dc.date.issued
2011-06  
dc.identifier.citation
Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo; Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus; Company of Biologists; Development; 138; 12; 6-2011; 2567-2579  
dc.identifier.issn
0950-1991  
dc.identifier.uri
http://hdl.handle.net/11336/67259  
dc.description.abstract
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Company of Biologists  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Β-Catenin  
dc.subject
Bcne  
dc.subject
Brain  
dc.subject
Dorsal-Anterior Development  
dc.subject
Notch  
dc.subject
Xenopus  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-01-02T19:56:43Z  
dc.journal.volume
138  
dc.journal.number
12  
dc.journal.pagination
2567-2579  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Cambridge  
dc.description.fil
Fil: Acosta , Helena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina  
dc.description.fil
Fil: Lopez, Silvia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina  
dc.description.fil
Fil: Revinski, Diego Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina  
dc.description.fil
Fil: Carrasco, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina  
dc.journal.title
Development  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1242/dev.061143  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/138/12/2567  

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