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dc.contributor.author
Gigena, Nicolás
dc.contributor.author
Alamino, Vanina Alejandra
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Montesinos, Maria del Mar
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Nazar, Magalí
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Louzada, Ruy A.
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Wajner, Simone M.
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Maia, Ana L.
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Masini, Ana María
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Carvalho, Denise P.
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Cremaschi, Graciela Alicia
dc.contributor.author
Pellizas, Claudia Gabriela
dc.date.available
2018-12-27T16:08:18Z
dc.date.issued
2017-02
dc.identifier.citation
Gigena, Nicolás; Alamino, Vanina Alejandra; Montesinos, Maria del Mar; Nazar, Magalí; Louzada, Ruy A.; et al.; Dissecting thyroid hormone transport and metabolism in dendritic cells; BioScientifica; Journal of Endocrinology; 232; 2; 2-2017; 337-350
dc.identifier.issn
0022-0795
dc.identifier.uri
http://hdl.handle.net/11336/67063
dc.description.abstract
We reported thyroid hormone (TH) receptor expression in murine dendritic cells (DCs) and 3,5,3'-triiodothyronine (T3)-dependent stimulation of DC maturation and ability to develop a Th1-type adaptive response. Moreover, an increased DC capacity to promote antigen-specific cytotoxic T-cell activity, exploited in a DC-based antitumor vaccination protocol, was revealed. However, putative effects of the main circulating TH, l-thyroxine (T4) and the mechanisms of TH transport and metabolism at DC level, crucial events for TH action at target cell level, were not known. Herein, we show that T4 did not reproduce those registered T3-dependent effects, finding that may reflect a homoeostatic control to prevent unspecific systemic activation of DCs. Besides, DCs express MCT10 and LAT2 TH transporters, and these cells mainly transport T3 with a favored involvement of MCT10 as its inhibition almost prevented T3 saturable uptake mechanism and reduced T3-induced IL-12 production. In turn, DCs express iodothyronine deiodonases type 2 and 3 (D2, D3) and exhibit both enzymatic activities with a prevalence towards TH inactivation. Moreover, T3 increased MCT10 and LAT2 expression and T3 efflux from DCs but not T3 uptake, whereas it induced a robust induction of D3 with a parallel slight reduction in D2. These findings disclose pivotal events involved in the mechanism of action of THs on DCs, providing valuable tools for manipulating the immunogenic potential of these cells. Furthermore, they broaden the knowledge of the TH mechanism of action at the immune system network.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioScientifica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dendritic Cells (Dcs)
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Th Mechanism of Action
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Th Metabolism
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Th Transport
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Thyroid Hormones (Ths)
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Triiodothyronine (T3)
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Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Dissecting thyroid hormone transport and metabolism in dendritic cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-22T16:48:09Z
dc.journal.volume
232
dc.journal.number
2
dc.journal.pagination
337-350
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Gigena, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Alamino, Vanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Montesinos, Maria del Mar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Nazar, Magalí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Louzada, Ruy A.. Universidade Federal do Rio de Janeiro; Brasil
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Fil: Wajner, Simone M.. Universidade Federal do Rio Grande do Sul; Brasil
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Fil: Maia, Ana L.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Masini, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Carvalho, Denise P.. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil
Fil: Cremaschi, Graciela Alicia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Pellizas, Claudia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
Journal of Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1530/JOE-16-0423
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://joe.bioscientifica.com/view/journals/joe/232/2/337.xml
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