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dc.contributor.author
Casais, Patricia
dc.contributor.author
Meschengieser, Susana S.
dc.contributor.author
Gennari, Laura C.
dc.contributor.author
Alberto, Maria Fabiana
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Sánchez Luceros, Analía Gabriela
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Blanco, Alicia Noemi
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Lazzari, María Ángela
dc.date.available
2018-12-13T19:46:58Z
dc.date.issued
2004-01
dc.identifier.citation
Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Sánchez Luceros, Analía Gabriela; et al.; Morbidity of lupus anticoagulants in children: A single institution experience; Pergamon-Elsevier Science Ltd; Thrombosis Research; 114; 4; 1-2004; 245-249
dc.identifier.issn
0049-3848
dc.identifier.uri
http://hdl.handle.net/11336/66454
dc.description.abstract
Introduction: The lupus anticoagulant (LA) and the anticardiolipin antibodies (ACA) are the antiphospholipid antibodies more relevant clinically. Their clinical manifestations are diverse with most patients being asymptomatic while others present venous or arterial thrombosis, and more rarely, bleeding. Our objectives were to evaluate clinical presentation of LA in children and to correlate it to LA behavior. Patients and methods: A retrospective cohort of patients (under 18 years old) who had a positive determination of LA followed by at least another determination of LA at a variable period was evaluated. Personal and family history, including infectious diseases temporally related to the event, were recorded. The screening of other coagulation disorders was performed according to symptoms, family history or laboratory results. Results: Thirty-six patients were evaluated, median age was 10.8 years old, and 52.8% were female. Asymptomatic patients were 19.4% (7/36) of study population. Bleeding and thrombosis were found in 52.8% and 27.8%, respectively. Median LA determinations per patient were 3. von Willebrand disease was diagnosed in 66.7% of patients consulting for bleeding. A concomitant hemostatic defect was found in 8/10 patients with thrombosis (p=0.003). LA behavior was not uniform and not correlated to symptoms. Conclusions: Most LA found in children is incidental and asymptomatic. In children with bleeding, LA might be a fortuitous finding associated with VWD. The persistence of LA does not imply a higher risk of thrombosis. © 2004 Elsevier Ltd. All rights reserved.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bleeding
dc.subject
Thrombophilia
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Thrombosis
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Von Willebrand Disease
dc.subject.classification
Medicina Critica y de Emergencia
dc.subject.classification
Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Morbidity of lupus anticoagulants in children: A single institution experience
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-22T14:54:55Z
dc.journal.volume
114
dc.journal.number
4
dc.journal.pagination
245-249
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Elmsford
dc.description.fil
Fil: Casais, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Meschengieser, Susana S.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Alberto, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Blanco, Alicia Noemi. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Thrombosis Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.thromres.2004.06.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0049384804003159


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