Artículo
Morbidity of lupus anticoagulants in children: A single institution experience
Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Sánchez Luceros, Analía Gabriela
; Blanco, Alicia Noemi; Lazzari, María Ángela
Fecha de publicación:
01/2004
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Thrombosis Research
ISSN:
0049-3848
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Introduction: The lupus anticoagulant (LA) and the anticardiolipin antibodies (ACA) are the antiphospholipid antibodies more relevant clinically. Their clinical manifestations are diverse with most patients being asymptomatic while others present venous or arterial thrombosis, and more rarely, bleeding. Our objectives were to evaluate clinical presentation of LA in children and to correlate it to LA behavior. Patients and methods: A retrospective cohort of patients (under 18 years old) who had a positive determination of LA followed by at least another determination of LA at a variable period was evaluated. Personal and family history, including infectious diseases temporally related to the event, were recorded. The screening of other coagulation disorders was performed according to symptoms, family history or laboratory results. Results: Thirty-six patients were evaluated, median age was 10.8 years old, and 52.8% were female. Asymptomatic patients were 19.4% (7/36) of study population. Bleeding and thrombosis were found in 52.8% and 27.8%, respectively. Median LA determinations per patient were 3. von Willebrand disease was diagnosed in 66.7% of patients consulting for bleeding. A concomitant hemostatic defect was found in 8/10 patients with thrombosis (p=0.003). LA behavior was not uniform and not correlated to symptoms. Conclusions: Most LA found in children is incidental and asymptomatic. In children with bleeding, LA might be a fortuitous finding associated with VWD. The persistence of LA does not imply a higher risk of thrombosis. © 2004 Elsevier Ltd. All rights reserved.
Palabras clave:
Bleeding
,
Thrombophilia
,
Thrombosis
,
Von Willebrand Disease
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Sánchez Luceros, Analía Gabriela; et al.; Morbidity of lupus anticoagulants in children: A single institution experience; Pergamon-Elsevier Science Ltd; Thrombosis Research; 114; 4; 1-2004; 245-249
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