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dc.contributor.author Romeo, Hernan Esteban
dc.contributor.author Fanovich, Maria Alejandra
dc.date.available 2018-12-12T17:51:22Z
dc.date.issued 2008-10-21
dc.identifier.citation Romeo, Hernan Esteban; Fanovich, Maria Alejandra; TTCP-DCPA Based Calcium Phosphate Cements Containing Hybrid Microparticles as Drug Carriers; Trans Tech Publications; Key Engineering Materials; 396-398; 21-10-2008; 489-492
dc.identifier.issn 1662-9795
dc.identifier.uri http://hdl.handle.net/11336/66340
dc.description.abstract In recent years, considerable attention has been focused on the development of new composite materials for application as drug delivery systems. In this field, calcium phosphate cements (CPCs) are often employed as support to delivery of drugs, but their behavior has some drawback related to the so-called burst effect. The aim of this work was to develop new CPCs formulations from synthesized tetracalcium phosphate (TTCP), dicalcium phosphate anhydrous TTCP and drug-containing hybrid microparticles (DCHM). The main function of these DCHM is providing nuclei of high concentration of drugs into the CPCs. The DCHM were synthesized via the sol-gel method from a bridged precursor of the type (H3CO)3 – Bridge – (OCH3)3 and aspirin (AS) as model drug. The inorganic polycondensation reached 89.5 % as calculated by 29Si NMR. The analysis by small angle X-ray scattering (SAXS) reveled a short range structural ordering in the DCHM at molecular level. Effective incorporation of AS inside the microspheres was detected by FTIR spectroscopy. In vitro tests of DCHM according to ISO 10993-5 revealed non-cytotoxic behavior. Four CPCs formulations containing 0, 1, 5 and 10 wt % of DCHM, were evaluated. The presence of DCHM did not modify neither the degree of conversion to low-crystallinity HA nor the measured setting times of the CPCs, however, the amount of incorporated microparticles considerably affected the degree of porosity (macropores of 200 µm) and interconnectivity of the cement matrix.
dc.format application/pdf
dc.language.iso eng
dc.publisher Trans Tech Publications
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Calcium phosphate cements
dc.subject Hybrid materials
dc.subject Bone Cement
dc.subject Drug Carriers
dc.subject Hybrid Microspheres
dc.subject Hydroxyapatite (HAP)
dc.subject.classification Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Otras Biotecnologías de la Salud
dc.subject.classification Biotecnología de la Salud
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title TTCP-DCPA Based Calcium Phosphate Cements Containing Hybrid Microparticles as Drug Carriers
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-11-22T15:29:58Z
dc.identifier.eissn 1013-9826
dc.journal.volume 396-398
dc.journal.pagination 489-492
dc.journal.pais Suiza
dc.journal.ciudad Zurich
dc.description.fil Fil: Romeo, Hernan Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.journal.title Key Engineering Materials
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.scientific.net/KEM.396-398.489
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4028/www.scientific.net/KEM.396-398.489
dc.conicet.fuente unificacion


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  • Articulos(INTEMA) [1146]
    Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)