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dc.contributor.author
Fariña, Ana Clara
dc.contributor.author
Hirabara, Sandro
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Sain, Juliana
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Gonzalez, Marcela
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Curi, Rui
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Bernal, Claudio Adrian
dc.date.available
2018-12-11T18:18:26Z
dc.date.issued
2018-06
dc.identifier.citation
Fariña, Ana Clara; Hirabara, Sandro; Sain, Juliana; Gonzalez, Marcela; Curi, Rui; et al.; Influence of trans fatty acids on glucose metabolism in soleus muscle of rats fed diets enriched in or deprived of linoleic acid; Dr Dietrich Steinkopff Verlag; European Journal of Nutrition; 57; 4; 6-2018; 1343-1355
dc.identifier.issn
1436-6207
dc.identifier.uri
http://hdl.handle.net/11336/66260
dc.description.abstract
Purpose: Industrial trans fatty acid (TFA) intake leads to impaired glucose metabolism. However, the overall effects reported are inconsistent and vary with the dietary FA composition and TFA isomer type and levels. We investigated TFA effects on glucose uptake, incorporation and oxidation, and glycogen synthesis in incubated soleus muscle under basal conditions or after treatment with insulin and/or palmitate. Methods: Male Wistar rats were fed either linoleic acid (LA)-enriched (+LA) or LA-deprived (−LA) diet, supplemented (+LA + TFA or −LA + TFA) or not with TFA, for 60 days. Soleus muscle glucose metabolism was assessed in the absence or presence of insulin and/or palmitic acid. Results: Under basal conditions, TFA enhanced glucose uptake and oxidation regardless of the LA status. Both TFA-supplemented groups had lower insulin response to glucose metabolism. Under insulin-stimulated conditions, TFA prevented the palmitate inhibition of muscle glucose uptake and metabolism in the +LA + TFA group. Conclusion: Dietary TFA enhanced glucose utilization in incubated soleus muscle under basal conditions and prevented the palmitate-induced inhibition in insulin-stimulated conditions. However, TFA reduced the insulin response to glucose uptake and metabolism. The effects mentioned above were influenced by the FA profile modifications induced by the dietary LA levels, suggesting that lipid metabolization and incorporation into plasma membrane are important determining factors of glucose metabolism and insulin sensitivity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Dr Dietrich Steinkopff Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Glucose Incorporation
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Glucose Oxidation
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Glucose Uptake
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Glycogen Synthesis
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Linoleic Acid
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Trans Fatty Acids
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Influence of trans fatty acids on glucose metabolism in soleus muscle of rats fed diets enriched in or deprived of linoleic acid
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-11-27T16:32:05Z
dc.journal.volume
57
dc.journal.number
4
dc.journal.pagination
1343-1355
dc.journal.pais
Alemania
dc.journal.ciudad
Darmstadt
dc.description.fil
Fil: Fariña, Ana Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
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Fil: Hirabara, Sandro. Universidade de Sao Paulo; Brasil
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Fil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.description.fil
Fil: Gonzalez, Marcela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.description.fil
Fil: Curi, Rui. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.journal.title
European Journal of Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00394-017-1413-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00394-017-1413-3
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