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dc.contributor.author
Castro, Gabriela Tatiana  
dc.contributor.author
Filippa, Mauricio Andrés  
dc.contributor.author
Peralta, Cecilia Mariana  
dc.contributor.author
Davin, María Virginia  
dc.contributor.author
Almandoz, María Cristina  
dc.contributor.author
Gasull, Estela Isabel  
dc.date.available
2018-11-14T18:43:20Z  
dc.date.issued
2018-02  
dc.identifier.citation
Castro, Gabriela Tatiana; Filippa, Mauricio Andrés; Peralta, Cecilia Mariana; Davin, María Virginia; Almandoz, María Cristina; et al.; Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems; Oldenbourg Verlag; Zeitschrift für Physikalische Chemie; 232; 2; 2-2018; 257-280  
dc.identifier.issn
0942-9352  
dc.identifier.uri
http://hdl.handle.net/11336/64500  
dc.description.abstract
The solubilization and solvatochromic behavior of piroxicam (PRX) were analyzed using UV-vis spectroscopy in neat (protic and aprotic) and binary solvent mixtures. The effects of solvent dipolarity/polarizability and solvent?solute hydrogen bonding interactions on the absorption maxima were evaluated by means of the linear solvation energy relationship concept of Kamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. While, the PRX solubility depends on the solute?solvent specific interactions, polarizability and the cohesive forces of the solvent, manifested mainly by means of the Hildebrand?s solubility parameter. Preferential solvation (PS) was studied in 10 binary mixtures. A non-ideal behavior of the wavenumber curve as the function of analytical mole fraction of co-solvent was detected. Index of preferential solvation, as well as the influence of solvent parameters were calculated. The process of dissolution was analyzed in aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol. They were not spontaneous in all proportions, but when water concentration decreases in the mixtures, the process becomes more spontaneous.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Oldenbourg Verlag  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Binary Mixtures  
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Piroxicam  
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Preferential Solvation  
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Solvatochomism  
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Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-10-23T17:40:32Z  
dc.journal.volume
232  
dc.journal.number
2  
dc.journal.pagination
257-280  
dc.journal.pais
Alemania  
dc.journal.ciudad
Munich  
dc.description.fil
Fil: Castro, Gabriela Tatiana. Universidad Nacional de San Luis; Argentina  
dc.description.fil
Fil: Filippa, Mauricio Andrés. Universidad Nacional de San Luis; Argentina  
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Fil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina  
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Fil: Davin, María Virginia. Universidad Nacional de San Luis; Argentina  
dc.description.fil
Fil: Almandoz, María Cristina. Universidad Nacional de San Luis; Argentina  
dc.description.fil
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis; Argentina  
dc.journal.title
Zeitschrift für Physikalische Chemie  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.degruyter.com/view/j/zpch.ahead-of-print/zpch-2017-0946/zpch-2017-0946.xml  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/zpch-2017-0946