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dc.contributor.author
Pietri, Thomas
dc.contributor.author
Romano, Sebastián A.
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Pérez Schuster, Verónica
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Boulanger Weill, Jonathan
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Candat, Virginie
dc.contributor.author
Sumbre, Germán
dc.date.available
2018-11-13T21:05:30Z
dc.date.issued
2017-05
dc.identifier.citation
Pietri, Thomas; Romano, Sebastián A.; Pérez Schuster, Verónica; Boulanger Weill, Jonathan; Candat, Virginie; et al.; The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs; Elsevier; Cell Reports; 19; 5; 5-2017; 939-948
dc.identifier.issn
2211-1247
dc.identifier.uri
http://hdl.handle.net/11336/64413
dc.description.abstract
The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Behavior
dc.subject
Development of Spontaneous Activity
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Neuronal Circuit Dynamics
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Optic Tectum
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Retinal Input
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Visual System
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Zebrafish
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-23T18:08:54Z
dc.journal.volume
19
dc.journal.number
5
dc.journal.pagination
939-948
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Pietri, Thomas. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia. New Jersey Institute of Technology; Estados Unidos
dc.description.fil
Fil: Romano, Sebastián A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Pérez Schuster, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Candat, Virginie. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
dc.description.fil
Fil: Sumbre, Germán. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
dc.journal.title
Cell Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2017.04.015
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124717304904
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