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dc.contributor.author
Aybar Odstrcil, Ana del Carmen
dc.contributor.author
Acebal, Silvia Graciela
dc.contributor.author
Diaz Ricci, Juan Carlos
dc.contributor.author
Mandalunis, Patricia Mónica
dc.date.available
2018-10-22T20:54:47Z
dc.date.issued
2010-05
dc.identifier.citation
Aybar Odstrcil, Ana del Carmen; Acebal, Silvia Graciela; Diaz Ricci, Juan Carlos; Mandalunis, Patricia Mónica; Effect of arsenic in endochondral ossification of experimental animals; Elsevier Gmbh; Experimental And Toxicologic Pathology; 62; 3; 5-2010; 243-249
dc.identifier.issn
0940-2993
dc.identifier.uri
http://hdl.handle.net/11336/62889
dc.description.abstract
Arsenic (As) toxicity is a global health problem affecting millions of people, the most toxic forms being Arsenites [As(III)] and Arsenates [As(V)]. Arsenic intoxication can occur through different exposure routes. The aim of the present work was to determine the effect of As on endochondral ossification and bone remodeling in experimental animals, by means of biochemical, histologic, and histomorphometric determinations.Sixteen male Wistar rats, 100g body weight (b.w.), were divided into two groups: experimental group (n=8), treated with 10mg/l of NaAsO2 in their drinking water, receiving 0.21mg/kgb.w./day during 45 days; and control group (n=8) remained untreated. On day 45, blood samples were obtained by cardiac puncture to perform hematologic blood counts and biochemical determination. The animals were killed, the tibiae, femurs, kidneys and livers were resected, fixed in formalin and processed histologically. Tibia and femur sections were obtained and stained with H&E. The following histomorphometric parameters were determined on tibia and femur sections: bone volume (BV/TV), thickness of growth plate cartilage (GPC.Th) and thickness of hypertrophic zone (HpZ.Th).Biochemical determinations showed that experimental animals exhibited neutrophilia and a decrease in lymphocytes and monocytes. As levels were below 1 μg/dl in both groups. The femur sections of the experimental group showed (1) a statistically significant increase in total growth cartilage plate thickness (. p<0.05) at the expense of the hypertrophic zone (. p<0.05); (2) subchondral trabecular bone sealed to the growth plate with a non-significant increase in primary spongiosa bone volume. These results suggest that As alters endochondral ossification.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Arsenic
dc.subject
Bone Histomorphometry
dc.subject
Endochondral Ossification
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effect of arsenic in endochondral ossification of experimental animals
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-10-17T15:04:25Z
dc.journal.volume
62
dc.journal.number
3
dc.journal.pagination
243-249
dc.journal.pais
Alemania
dc.journal.ciudad
Alemania
dc.description.fil
Fil: Aybar Odstrcil, Ana del Carmen. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Acebal, Silvia Graciela. Universidad Nacional de Tucumán. Facultad de Odontología; Argentina
dc.description.fil
Fil: Diaz Ricci, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
dc.description.fil
Fil: Mandalunis, Patricia Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
dc.journal.title
Experimental And Toxicologic Pathology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.etp.2009.04.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0940299309001663


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