Artículo
Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations
Altszyler Lemcovich, Edgar Jaim
; Ventura, Alejandra
; Colman Lerner, Alejandro Ariel
; Chernomoretz, Ariel
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Fecha de publicación:
06/2017
Editorial:
Public Library of Science
Revista:
Plos One
ISSN:
1932-6203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive modules can enhance the system's ultrasensitivity, how a given combination of layers affects a cascade's ultrasensitivity remains an open question for the general case. Here, we introduce a methodology that allows us to determine the presence of sequestration effects and to quantify the relative contribution of each module to the overall cascade's ultrasensitivity. The proposed analysis framework provides a natural link between global and local ultrasensitivity descriptors and it is particularly wellsuited to characterize and understand mathematical models used to study real biological systems. As a case study, we have considered three mathematical models introduced by O'Shaughnessy et al. to study a tunable synthetic MAPK cascade, and we show how our methodology can help modelers better understand alternative models.
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Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Citación
Altszyler Lemcovich, Edgar Jaim; Ventura, Alejandra; Colman Lerner, Alejandro Ariel; Chernomoretz, Ariel; Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations; Public Library of Science; Plos One; 12; 6; 6-2017; 1-18
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