Mostrar el registro sencillo del ítem
dc.contributor.author
Bianchini, Romina Marcela
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Kaufman, Teodoro Saul
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2016-06-06T21:28:45Z
dc.date.issued
2013-06
dc.identifier.citation
Bianchini, Romina Marcela; Kaufman, Teodoro Saul; A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions; Wiley; International Journal of Chemical Kinetics; 45; 11; 6-2013; 734-745
dc.identifier.issn
0538-8066
dc.identifier.uri
http://hdl.handle.net/11336/6082
dc.description.abstract
The analysis of UV-spectrophotometric data with second-order chemometrics techniques, including multivariate curve resolution with alternating least-squares (MCR-ALS) and hybrid hard- and soft MCR (HS-MCR), was examined as an alternative tool for studying the kinetics of drug degradation under stress conditions, employing valsartan (VAL) as a model drug. Despite small structural and spectroscopic differences between VAL and its degradation products, MCR-ALS and HS-MCR were able to detect the generation of two photoneutral degradation products (DP-1 and DP-2) and a single acid hydrolysis product (DP-3), providing good approximations to their pure spectra and concentration profiles, from which estimations of the kinetic profiles and rate constants were obtained. Kinetic models based on first-order reactions explained the degradation processes. MCR-ALS and HS-MCR analyses yielded similar rate constants; however, the latter was capable of more properly fitting the experimental data to a kinetic model in the case of drug photolysis. The results were confirmed by comparison with data obtained by HPLC analysis of the degraded samples.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Valsartan
dc.subject
Mcr-Als
dc.subject
Kinetics
dc.subject
Degradation Products
dc.subject.classification
Química Analítica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Químicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-06-01T13:32:27Z
dc.journal.volume
45
dc.journal.number
11
dc.journal.pagination
734-745
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Bianchini, Romina Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.description.fil
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.journal.title
International Journal of Chemical Kinetics
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/kin.20808/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/10.1002/kin.20808
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/kin.20808
Archivos asociados