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dc.contributor.author
Raimondo, Federico
dc.contributor.author
Rohaut, Benjamin
dc.contributor.author
Demertzi, Athena
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Valente, Melanie
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Engemann, Denis
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Salti, Moti
dc.contributor.author
Fernandez Slezak, Diego
dc.contributor.author
Naccache, Lionel
dc.contributor.author
Sitt, Jacobo Diego
dc.date.available
2018-09-19T19:37:05Z
dc.date.issued
2017-10
dc.identifier.citation
Raimondo, Federico; Rohaut, Benjamin; Demertzi, Athena; Valente, Melanie; Engemann, Denis; et al.; Brain–heart interactions reveal consciousness in noncommunicating patients; Wiley-liss, Div John Wiley & Sons Inc; Annals Of Neurology; 82; 4; 10-2017; 578-591
dc.identifier.issn
0364-5134
dc.identifier.uri
http://hdl.handle.net/11336/60319
dc.description.abstract
Objective: We here aimed at characterizing heart–brain interactions in patients with disorders of consciousness. We tested how this information impacts data-driven classification between unresponsive and minimally conscious patients. Methods: A cohort of 127 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS; n = 70) and minimally conscious state (MCS; n = 57) were presented with the local–global auditory oddball paradigm, which distinguishes 2 levels of processing: short-term deviation of local auditory regularities and global long-term rule violations. In addition to previously validated markers of consciousness extracted from electroencephalograms (EEG), we computed autonomic cardiac markers, such as heart rate (HR) and HR variability (HRV), and cardiac cycle phase shifts triggered by the processing of the auditory stimuli. Results: HR and HRV were similar in patients across groups. The cardiac cycle was not sensitive to the processing of local regularities in either the VS/UWS or MCS patients. In contrast, global regularities induced a phase shift of the cardiac cycle exclusively in the MCS group. The interval between the auditory stimulation and the following R peak was significantly shortened in MCS when the auditory rule was violated. When the information for the cardiac cycle modulations and other consciousness-related EEG markers were combined, single patient classification performance was enhanced compared to classification with solely EEG markers. Interpretation: Our work shows a link between residual cognitive processing and the modulation of autonomic somatic markers. These results open a new window to evaluate patients with disorders of consciousness via the embodied paradigm, according to which body–brain functions contribute to a holistic approach to conscious processing. Ann Neurol 2017;82:578–591.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, Div John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Heart Beat
dc.subject
Machine Learning
dc.subject
Artificial Intelligence
dc.subject.classification
Ciencias de la Computación
dc.subject.classification
Ciencias de la Computación e Información
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Brain–heart interactions reveal consciousness in noncommunicating patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-09-17T19:30:26Z
dc.journal.volume
82
dc.journal.number
4
dc.journal.pagination
578-591
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Raimondo, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación En Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación En Ciencias de la Computacion; Argentina. Universite de Paris VI; Francia
dc.description.fil
Fil: Rohaut, Benjamin. Inserm; Francia
dc.description.fil
Fil: Demertzi, Athena. Inserm; Francia
dc.description.fil
Fil: Valente, Melanie. Inserm; Francia
dc.description.fil
Fil: Engemann, Denis. Inserm; Francia
dc.description.fil
Fil: Salti, Moti. University of the Negev; Israel
dc.description.fil
Fil: Fernandez Slezak, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación En Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación En Ciencias de la Computacion; Argentina
dc.description.fil
Fil: Naccache, Lionel. Inserm; Francia
dc.description.fil
Fil: Sitt, Jacobo Diego. Inserm; Francia
dc.journal.title
Annals Of Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25045
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ana.25045
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