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Artículo

Lactobacillus rhamnosus RC007 intended for feed additive: Immune-stimulatory properties and ameliorating effects on TNBS-induced colitis

Dogi, Cecilia AnaIcon ; García, Gisela RominaIcon ; de Moreno, Maria AlejandraIcon ; Greco, Cecilia Rosa; Cavaglieri, Lilia ReneéIcon
Fecha de publicación: 06/04/2016
Editorial: Wageningen Academic Publishers
Revista: Beneficial Microbes
ISSN: 1876-2883
e-ISSN: 1876-2891
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Lactobacillus rhamnosus RC007 is a potential probiotic bacterium that can exert beneficial effects as supplement for animal feed, by improving the immune status in healthy host, and by providing therapeutic benefits to infected/inflamed animals. The aim of the present work was to evaluate in vivo the beneficial properties of L. rhamnosus RC007, intended for animal feed, when administered to healthy and trinitro-benzene-sulfonic-acid (TNBS) colitis induced BALB/c mice. The administration of L. rhamnosus RC007 to healthy mice during 10 days increased the phagocytic activity of peritoneal macrophages and the number of immunoglobulin A+ cells in the lamina proper of the small intestine. Significant increases of monocyte chemotactic protein 1, interleukin (IL)-10 and tumour necrosis factor alpha (TNF-α) concentrations, and in the ratio between anti- and pro-inflammatory cytokines (IL-10/TNF-α) were observed in intestinal fluids after administration of bacteria. In the inflammation model, less body weight loss, macroscopic and histological damages in the large intestine were accompanied by increased IL-10/TNF-α ratio in the intestinal fluids of mice from the L. rhamnosus-TNBS group when compared to the TNBS group. In a healthy host, the oral administration of L. rhamnosus RC007 kept the gut immune system stimulated allowing a faster response to noxious stimulus. Mice that received L. rhamnosus RC007 also decreased the severity of the intestinal inflammation.
Palabras clave: Animal Feed , Gut Inflammation , Immune Modulation , Immune System , Lactic Acid Bacteria
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/58957
DOI: http://dx.doi.org/10.3920/BM2015.0147
URL: https://www.wageningenacademic.com/doi/10.3920/BM2015.0147
Colecciones
Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Dogi, Cecilia Ana; García, Gisela Romina; de Moreno, Maria Alejandra; Greco, Cecilia Rosa; Cavaglieri, Lilia Reneé; Lactobacillus rhamnosus RC007 intended for feed additive: Immune-stimulatory properties and ameliorating effects on TNBS-induced colitis; Wageningen Academic Publishers; Beneficial Microbes; 7; 4; 6-4-2016; 539-547
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