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dc.contributor.author
Sain, Juliana
dc.contributor.author
González, Marcela Aída
dc.contributor.author
Lavandera, Jimena Veronica
dc.contributor.author
Scalerandi, María Victoria
dc.contributor.author
Bernal, Claudio Adrian
dc.date.available
2018-09-03T17:53:02Z
dc.date.issued
2016-08
dc.identifier.citation
Sain, Juliana; González, Marcela Aída; Lavandera, Jimena Veronica; Scalerandi, María Victoria; Bernal, Claudio Adrian; The effects of trans-fatty acids on TAG regulation in mice depend on dietary unsaturated fatty acids; Cambridge University Press; British Journal of Nutrition; 116; 4; 8-2016; 611-620
dc.identifier.issn
0007-1145
dc.identifier.uri
http://hdl.handle.net/11336/58079
dc.description.abstract
The aim of this study was to investigate the effects of trans-fatty acids (TFA) on liver and serum TAG regulation in mice fed diets containing different proportions of n-3, n-6 and n-9 unsaturated fatty acids (UFA) from olive (O), maize (C) or rapeseed (R) oils partially substituted or not with TFA (Ot, Ct and Rt, respectively). Male CF1 mice were fed (30 d) one of these diets. The effects of the partial substitution (1 %, w/w) of different UFA with TFA on the activity and expression of hepatic enzymes involved in lipogenesis and fatty acids oxidation were evaluated, as well as their transcription factor expressions. Some of the mechanisms involved in the serum TAG regulation, hepatic VLDL rich in TAG (VLDL-TAG) secretion rate and lipoprotein lipase (LPL) activity were assessed. In liver, TFA induced an increase in TAG content in the Ot and Rt groups, and this effect was associated with an imbalance between lipogenesis and β-oxidation. In the Ot group, exacerbated lipogenesis may be one of the mechanisms responsible for the liver steatosis induced by TFA, whereas in Rt it has been related to a decreased β-oxidation, compared with their respective controls. The enhanced hepatic VLDL-TAG secretion in the Ot and Rt groups was compensated with a differential removal of TAG by LPL enzyme in extrahepatic tissues, leading to unchanged serum TAG levels. In brief, the effects of low levels of TFA on liver and serum TAG regulation in mice depend on the dietary proportions of n-3, n-6 and n-9 UFA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dietary Fat
dc.subject
Lipogenesis
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Lipoprotein Lipase
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Tag Metabolism
dc.subject.classification
Nutrición, Dietética
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Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The effects of trans-fatty acids on TAG regulation in mice depend on dietary unsaturated fatty acids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-30T13:30:59Z
dc.identifier.eissn
1475-2662
dc.journal.volume
116
dc.journal.number
4
dc.journal.pagination
611-620
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Sain, Juliana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.description.fil
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.description.fil
Fil: Lavandera, Jimena Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.description.fil
Fil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.description.fil
Fil: Bernal, Claudio Adrian. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
dc.journal.title
British Journal of Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bit.ly/2NeGv7s
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0007114516002415
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