Artículo
Lactococcus lactis SpOx spontaneous mutants: A family of oxidative-stress-resistant dairy strains
Rochat, Tatiana; Gratadoux, Jean Jacques; Cortier, Gerard; Coqueran, Berard; Nader, Maria Elena Fatima
; Gruss, Alexandra; Langella, Philippe
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Fecha de publicación:
05/2005
Editorial:
American Society for Microbiology
Revista:
Applied And Environmental Microbiology
ISSN:
0099-2240
e-ISSN:
1098-5336
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Numerous industrial bacteria generate hydrogen peroxide (H 2O2), which may inhibit the growth of other bacteria in mixed ecosystems. We isolated spontaneous oxidative-stress-resistant (SpOx) Lactococcus lactis mutants by using a natural selection method with milk-adapted strains on dairy culture medium containing H2O2. Three SpOx mutants displayed greater H2O2 resistance. One of them, SpOx3, demonstrated better behavior in different oxidative-stress situations: (i) higher long-term survival upon aeration in LM17 and milk and (ii) the ability to grow with H2O2-producing Lactobacillus delbrueckii subsp. delbrueckii strains. Furthermore, the transit kinetics of the SpOx3 mutant in the digestive tract of a human flora-associated mouse model was not affected.
Palabras clave:
Lactobacilli
,
Hydrogen Peroxide
,
Oxidative Stress
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Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Rochat, Tatiana; Gratadoux, Jean Jacques; Cortier, Gerard; Coqueran, Berard; Nader, Maria Elena Fatima; et al.; Lactococcus lactis SpOx spontaneous mutants: A family of oxidative-stress-resistant dairy strains; American Society for Microbiology; Applied And Environmental Microbiology; 71; 5; 5-2005; 2782-2788
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