Artículo
Yogurt: Effect on leukocytes and blood coagulation in an acute liver injury model
Haro, Ana Cecilia
; Lazarte, Sandra Stella; Zelaya, María Hortensia del Rosario
; Alvarez, Gladis Susana
; Agüero, Graciela
Fecha de publicación:
08/2009
Editorial:
Mary Ann Liebert
Revista:
Journal Of Medicinal Food
ISSN:
1096-620X
e-ISSN:
1557-7600
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This study determined whether cow or goat yogurt administration has a preventive effect on the hepatic damage undergone during an acute liver injury. Acute liver injury was induced by an intraperitoneal injection of d-galactosamine. Groups of mice were fed with cow or goat yogurt for 2 days or 7 days before the d-galactosamine injection. Blood and liver samples were obtained 12 hours after d-galactosamine inoculation. d-Galactosamine induced an increase in serum aminotransaminases, a reduction in the number of blood leukocytes, an enhancement in neutrophil myeloperoxidase activity, a recruitment of leukocytes toward the liver, an increase in cell death, and an alteration in prothrombin time, activated partial thromboplastin time, and fibrinogen levels. Treatment with cow or goat yogurt was effective at increasing leukocyte number and decrease myeloperoxidase activity. We also observed a decrease in leukocyte accumulation in the liver and a reduction in cell death. Activated partial thromboplastin time and fibrinogen were normalized, but prothrombin time only showed an improvement without reaching normal values. Cow or goat yogurts were effective at protecting against an experimental acute liver injury, especially when administered for 7 days.
Palabras clave:
Acute Liver Injury
,
Blood Coagulation
,
Yogurt
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - NOA SUR)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NOA SUR
Articulos(CERELA)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Articulos de CENTRO DE REFERENCIA PARA LACTOBACILOS (I)
Citación
Haro, Ana Cecilia; Lazarte, Sandra Stella; Zelaya, María Hortensia del Rosario; Alvarez, Gladis Susana; Agüero, Graciela; Yogurt: Effect on leukocytes and blood coagulation in an acute liver injury model; Mary Ann Liebert; Journal Of Medicinal Food; 12; 4; 8-2009; 796-802
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