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dc.contributor.author
Romeo, Hernan Esteban
dc.contributor.author
Cameo, Mónica
dc.contributor.author
Choren, María V.
dc.contributor.author
Fanovich, Maria Alejandra
dc.date.available
2018-08-16T15:21:41Z
dc.date.issued
2011-04
dc.identifier.citation
Romeo, Hernan Esteban; Cameo, Mónica; Choren, María V.; Fanovich, Maria Alejandra; Functionalized bridged silsesquioxane-based nanostructured microspheres: ultrasound-assisted synthesis and in vitro cytotoxicity characterization; Springer; Journal of Materials Science: Materials In Medicine; 22; 4; 4-2011; 935-943
dc.identifier.issn
0957-4530
dc.identifier.uri
http://hdl.handle.net/11336/55892
dc.description.abstract
Different kinds of polymers have been employed in medicine as biomaterials for different purposes. In recent years, considerable attention has been focused on the development of new drug-delivery systems in order to increase bio-availability, sustain, localize and target drug action in the human body. The versatility of the sol-gel processing to synthesize nanostructured materials and the possibility of incorporating organic molecules into the matrix of the final hybrid material, represent a novel and attractive path to the synthesis of new functionalized hybrid biomaterials with advanced properties. In this work, acetylsalicylic acid (ASA)-functionalized hybrid microspheres based on bridged silsesquioxanes synthesized via ultrasound-assisted sol-gel processing, were characterized. An investigation concerning the cytotoxic response of these new microspheres on CHO-K1 cells was accomplished based on ISO 10993-5 standard (Biological Evaluation of Medical Devices). Microspheres incorporating ASA showed a cytotoxic effect when pure extracts of the microspheres were analyzed, however, they strongly diminished their cytotoxicity as the extracts were diluted. When a 10% concentration extract was employed, hybrid microspheres were shown to be non cytotoxic. These results are promising for considering these novel functionalized organic-inorganic microspheres as potential drug-carriers to be employed in drug delivery-related applications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Self-Assembly
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Microspheres
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Drug-Carriers
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Cell Culture
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Cytotoxicity
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Recubrimientos y Películas
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Functionalized bridged silsesquioxane-based nanostructured microspheres: ultrasound-assisted synthesis and in vitro cytotoxicity characterization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-08-13T17:23:42Z
dc.identifier.eissn
1573-4838
dc.journal.volume
22
dc.journal.number
4
dc.journal.pagination
935-943
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Romeo, Hernan Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Cameo, Mónica. No especifica;
dc.description.fil
Fil: Choren, María V.. No especifica;
dc.description.fil
Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.journal.title
Journal of Materials Science: Materials In Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10856-011-4261-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10856-011-4261-3
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