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dc.contributor.author
Driemeier, D.
dc.contributor.author
Colodel, E. M.
dc.contributor.author
Gimeno, Eduardo Juan
dc.contributor.author
Barros, S. S.
dc.date.available
2018-07-30T18:50:54Z
dc.date.issued
2000-03
dc.identifier.citation
Driemeier, D.; Colodel, E. M.; Gimeno, Eduardo Juan; Barros, S. S.; Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats; American College of Veterinary Pathologists; Veterinary Pathology; 37; 2; 3-2000; 153-159
dc.identifier.issn
0300-9858
dc.identifier.uri
http://hdl.handle.net/11336/53451
dc.description.abstract
A neurologic disease characterized by ataxia, hypermetria, hyperesthesia, and muscle tremors of the head and neck was observed for 2 years in a flock of 28 Anglo-Nubian and Saanen goats on a farm with 5 ha of pasture. Six newborns died during the first week of life, and five abortions were recorded. The predominant plant in the pasture was Sida carpinifolia. The disease was reproduced experimentally in two goats by adminisiration of this plant. Three goats with spontaneous disease and the two experimental animals were euthanatized and necropsied. No significant gross lesions were observed. Fragments of several organs, including the central nervous system, were processed for histopathology. Small fragments of the cerebellar cortex, liver, and pancreas of two spontaneously poisoned goats and two experimentally poisoned goats were processed for electron microscopy. Multiple cytoplasm vacuoles in hepatocytes, acinai pancreatic cells, and neurons, especially Purkinje cells, were the most striking microscopic lesions in the five animals. Ultrastructural changes included membrane-bound vacuoles in hepatocytes, Kupffer cells, acinar pancreatic cells, Purkinje cells, and the small neurons of the granular cell layer of the cerebellum. Paraffin-embedded sections of the cerebellum and pancreas were submitted for lectin histochemical analysis. The vacuoles in different cerebellar and acinar pancreatic cells reacted strongly to the following lectins: Concanavalia ensiformis, Triticum vulgaris, and succinylated Triticum vulgaris. The pattern of staining, analyzed in Purkinje cells and acinar pancreatic cells coincides with results reported for both swainsonine toxicosis and inherited mannosidosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American College of Veterinary Pathologists
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Central Nervous System
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Electron Microscopy
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Goats
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Lectin Histochemistry
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Lysosomes
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Pancreas
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Poisonous Plants
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Sida Carpinifolia
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Storage Disease
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Otras Ciencias Veterinarias
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Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Lysosomal Storage Disease Caused by Sida carpinifolia Poisoning in Goats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-23T17:53:48Z
dc.journal.volume
37
dc.journal.number
2
dc.journal.pagination
153-159
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Driemeier, D.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Colodel, E. M.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil
dc.journal.title
Veterinary Pathology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1354/vp.37-2-153
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1354/vp.37-2-153
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