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dc.contributor.author
Bastolla, Ugo
dc.contributor.author
Dehouck, Yves
dc.contributor.author
Echave, Julián
dc.date.available
2018-07-27T17:45:00Z
dc.date.issued
2017-02
dc.identifier.citation
Bastolla, Ugo; Dehouck, Yves; Echave, Julián; What evolution tells us about protein physics, and protein physics tells us about evolution; Elsevier; Current Opinion In Structural Biology; 42; 2-2017; 59-66
dc.identifier.issn
0959-440X
dc.identifier.uri
http://hdl.handle.net/11336/53308
dc.description.abstract
The integration of molecular evolution and protein biophysics is an emerging theme that steadily gained importance during the last 15 years, significantly advancing both fields. The central integrative concept is the stability of the native state, although non-native conformations are increasingly recognized to play a major role, concerning, for example, aggregation, folding kinetics, or functional dynamics. Besides molecular requirements on fitness, the stability of native and alternative conformations is modulated by a variety of factors, including population size, selective pressure on the replicative system, which determines mutation rates and biases, and epistatic effects. We discuss some of the recent advances, open questions, and integrating views in protein evolution, in light of the many underlying trade-offs, correlations, and dichotomies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Protein
dc.subject
Evolution
dc.subject
Biophysics
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
What evolution tells us about protein physics, and protein physics tells us about evolution
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-25T13:51:28Z
dc.journal.volume
42
dc.journal.pagination
59-66
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Bastolla, Ugo. Centro de Biologia Molecular “Severo Ochoa”; España
dc.description.fil
Fil: Dehouck, Yves. Université Libre de Bruxelles. Machine Learning Group; Bélgica
dc.description.fil
Fil: Echave, Julián. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Current Opinion In Structural Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sbi.2016.10.020
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0959440X16301816
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