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dc.contributor.author
Chaves Ferreira, Miguel
dc.contributor.author
Krenn, Gerald
dc.contributor.author
Vasseur, Florence
dc.contributor.author
Barinov, Aleksandr
dc.contributor.author
Gonçalves, Pedro
dc.contributor.author
Azogui, Orly
dc.contributor.author
Cumano, Ana
dc.contributor.author
Li, Zhi
dc.contributor.author
Pellegrini, Sandra
dc.contributor.author
Rocha, Benedita
dc.contributor.author
Laderach, Diego Jose
dc.date.available
2018-07-20T20:13:39Z
dc.date.issued
2016-04
dc.identifier.citation
Chaves Ferreira, Miguel; Krenn, Gerald; Vasseur, Florence; Barinov, Aleksandr; Gonçalves, Pedro; et al.; The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells; BioMed Central; Biology Direct; 11; 1; 4-2016; 11-21
dc.identifier.issn
1745-6150
dc.identifier.uri
http://hdl.handle.net/11336/52795
dc.description.abstract
Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Cell Cycle
dc.subject
D Cyclins
dc.subject
Hematopoiesis
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-07-13T17:41:26Z
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
11-21
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Chaves Ferreira, Miguel. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Instituto de Medicina Molecular; Portugal
dc.description.fil
Fil: Krenn, Gerald. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
dc.description.fil
Fil: Vasseur, Florence. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
dc.description.fil
Fil: Barinov, Aleksandr. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
dc.description.fil
Fil: Gonçalves, Pedro. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
dc.description.fil
Fil: Azogui, Orly. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
dc.description.fil
Fil: Cumano, Ana. Inserm; Francia. Institut Pasteur; Francia
dc.description.fil
Fil: Li, Zhi. Inserm; Francia. Institut Pasteur; Francia
dc.description.fil
Fil: Pellegrini, Sandra. Inserm; Francia. Institut Pasteur; Francia
dc.description.fil
Fil: Rocha, Benedita. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
dc.description.fil
Fil: Laderach, Diego Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Inserm. Inmmunology- Immunopathology Immunotherapy; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
dc.journal.title
Biology Direct
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s13062-016-0122-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://biologydirect.biomedcentral.com/articles/10.1186/s13062-016-0122-9
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