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dc.contributor.author
Silva, Ana P.
dc.contributor.author
Filho, José Carlos C. L. S.
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da Costa Júnior, Joaquim S.
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Peláez, Walter José
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Faillace, Martín Sebastián
dc.contributor.author
Falcão Ferraz, Alexandre de B.
dc.contributor.author
David, Jorge M.
dc.contributor.author
Freitas, Rivelilson M.
dc.date.available
2018-07-04T14:25:40Z
dc.date.issued
2015-07
dc.identifier.citation
Silva, Ana P.; Filho, José Carlos C. L. S.; da Costa Júnior, Joaquim S.; Peláez, Walter José; Faillace, Martín Sebastián; et al.; Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart; Pharmaceutical Press-Royal Pharmaceutical Society Great Britian; Journal of Pharmacy and Pharmacology; 3; 7; 7-2015; 316-330
dc.identifier.issn
0022-3573
dc.identifier.uri
http://hdl.handle.net/11336/51160
dc.description.abstract
The major constituent from the hexane extract of the seeds of P. insignis is GFC (garcinielliptone FC). Doses of 25, 50and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline (vehicle) and orally administered for30, 90 and 120 consecutive days to adult Swiss mice. In this work, the repeated oral administration, in animals of both sexes,demonstrates that this compound is not able to induce mortality and/or behavioral changes in adult mice. In addition, body weightgain, feed intake and disposal of excreta were not altered by the administration of this compound with repeated doses. Furthermore,no differences in weight and macroscopic structure of the brain, liver, kidney, lung, heart and spleen between groups of male andfemale adult mice were observed after treatment. During the periods of treatment, GFC produced no significant changes onhaematological and biochemical parameters in male and female mice treated with all doses used. The aim of this study was toinvestigate the toxicological potential of GFC through behavioral, hematological, biochemical and morphological parameters inanimals in order to ensure the safe use of Platonia insignis in folk medicine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pharmaceutical Press-Royal Pharmaceutical Society Great Britian
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Platonia Insignis
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Clusiaceae
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Polyisoprenylated Benzophenones
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Biochemical Analyses
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Toxicity
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Salud Ocupacional
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-04T21:41:04Z
dc.identifier.eissn
2042-7158
dc.journal.volume
3
dc.journal.number
7
dc.journal.pagination
316-330
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Silva, Ana P.. Federal University of Piauí; Brasil
dc.description.fil
Fil: Filho, José Carlos C. L. S.. North Union of Parana; Brasil
dc.description.fil
Fil: da Costa Júnior, Joaquim S.. Federal Institute of Piauí; Brasil
dc.description.fil
Fil: Peláez, Walter José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Faillace, Martín Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
dc.description.fil
Fil: Falcão Ferraz, Alexandre de B.. Lutheran University of Brazil; Brasil
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Fil: David, Jorge M.. Institute Of Chemistry, Federal University Of Bahia; Brasil. Universidade Federal da Bahia; Brasil
dc.description.fil
Fil: Freitas, Rivelilson M.. Federal University of Bahia; Brasil
dc.journal.title
Journal of Pharmacy and Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.davidpublisher.org/index.php/Home/Article/index?id=16849.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.17265/2328-2150/2015.07.002
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