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dc.contributor.author Birba, Agustina
dc.contributor.author García Cordero, Indira Ruth
dc.contributor.author Kozono, Giselle
dc.contributor.author Legaz, Agustina
dc.contributor.author Ibáñez Barassi, Agustín Mariano
dc.contributor.author Sedeño, Lucas
dc.contributor.author García, Adolfo Martín
dc.date.available 2018-06-15T17:47:57Z
dc.date.issued 2017-09
dc.identifier.citation Birba, Agustina; García Cordero, Indira Ruth; Kozono, Giselle; Legaz, Agustina; Ibáñez Barassi, Agustín Mariano; et al.; Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease; Pergamon-Elsevier Science Ltd; Neuroscience and Biobehavioral Reviews; 80; 9-2017; 673-687
dc.identifier.issn 0149-7634
dc.identifier.uri http://hdl.handle.net/11336/48820
dc.description.abstract Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the “disrupted motor grounding hypothesis”, a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits). We focus on two relevant lesion models: Parkinson's and Huntington's disease. First, we describe the physiopathology of both conditions as models of progressive frontostriatal impairment. Then, we summarize works assessing action language, motor-language coupling, and syntax in samples at early and preclinical disease stages. To conclude, we discuss the implications of the evidence for neurolinguistic modeling, identify key issues to be addressed in future research, and discuss potential clinical implications. In brief, our work seeks to open new theoretical and translational avenues for embodied cognition research.
dc.format application/pdf
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ACTION LANGUAGE
dc.subject EMBODIED COGNITION
dc.subject FRONTOSTRIATAL CIRCUITS
dc.subject HUNTINGTON'S DISEASE
dc.subject MOTOR-LANGUAGE COUPLING
dc.subject PARKINSON'S DISEASE
dc.subject SYNTAX
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-06-13T15:08:41Z
dc.journal.volume 80
dc.journal.pagination 673-687
dc.journal.pais Estados Unidos
dc.journal.ciudad Nueva York
dc.description.fil Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil Fil: García Cordero, Indira Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil Fil: Kozono, Giselle. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
dc.description.fil Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
dc.description.fil Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia
dc.description.fil Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina
dc.journal.title Neuroscience and Biobehavioral Reviews
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neubiorev.2017.07.011
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0149763417300702
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)