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dc.contributor.author
Birba, Agustina
dc.contributor.author
García Cordero, Indira Ruth
dc.contributor.author
Kozono, Giselle
dc.contributor.author
Legaz, Agustina
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Ibáñez Barassi, Agustín Mariano
dc.contributor.author
Sedeño, Lucas
dc.contributor.author
García, Adolfo Martín
dc.date.available
2018-06-15T17:47:57Z
dc.date.issued
2017-09
dc.identifier.citation
Birba, Agustina; García Cordero, Indira Ruth; Kozono, Giselle; Legaz, Agustina; Ibáñez Barassi, Agustín Mariano; et al.; Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease; Pergamon-Elsevier Science Ltd; Neuroscience and Biobehavioral Reviews; 80; 9-2017; 673-687
dc.identifier.issn
0149-7634
dc.identifier.uri
http://hdl.handle.net/11336/48820
dc.description.abstract
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the “disrupted motor grounding hypothesis”, a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits). We focus on two relevant lesion models: Parkinson's and Huntington's disease. First, we describe the physiopathology of both conditions as models of progressive frontostriatal impairment. Then, we summarize works assessing action language, motor-language coupling, and syntax in samples at early and preclinical disease stages. To conclude, we discuss the implications of the evidence for neurolinguistic modeling, identify key issues to be addressed in future research, and discuss potential clinical implications. In brief, our work seeks to open new theoretical and translational avenues for embodied cognition research.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Action Language
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Embodied Cognition
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Frontostriatal Circuits
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Huntington'S Disease
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Motor-Language Coupling
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Parkinson'S Disease
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Syntax
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-13T15:08:41Z
dc.journal.volume
80
dc.journal.pagination
673-687
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil
Fil: García Cordero, Indira Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil
Fil: Kozono, Giselle. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
dc.description.fil
Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina
dc.description.fil
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia
dc.description.fil
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina
dc.journal.title
Neuroscience and Biobehavioral Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neubiorev.2017.07.011
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0149763417300702


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