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dc.contributor.author
Martínez Medina, Juan José
dc.contributor.author
Naso, Luciana Gissella
dc.contributor.author
Pérez, Ana L.
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Rizzi, Alberto Claudio
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Ferrer, Evelina Gloria
dc.contributor.author
Williams, Patricia Ana María
dc.date.available
2018-06-12T14:17:04Z
dc.date.issued
2017-01
dc.identifier.citation
Martínez Medina, Juan José; Naso, Luciana Gissella; Pérez, Ana L.; Rizzi, Alberto Claudio; Ferrer, Evelina Gloria; et al.; Antioxidant and anticancer effects and bioavailability studies of the flavonoid baicalin and its oxidovanadium(IV) complex; Elsevier Science Inc; Journal of Inorganic Biochemistry; 166; 1-2017; 150-161
dc.identifier.issn
0162-0134
dc.identifier.uri
http://hdl.handle.net/11336/48255
dc.description.abstract
Based on the knownantioxidant effect of flavonoids, baicalin (baic) found in roots of Scutellaria has been selected.Its coordination complex with the oxidovanadium(IV) cation, Na4[VO(baic)2].6H2O (VIVO(baic)), was synthesizedat pH 9 in ethanol and characterized by physicochemical methods. Spectrophotometric studies at pH 9 showed a ligand: metal stoichiometry of 2:1. By vibrational spectroscopy a coordination mode through the cis5-OH and 6-OH deprotonated groups is inferred. EPR spectroscopy shows an environment of four aryloxide (ArO−) groups in the equatorial plane of the V_O moiety, both in solution and in the solid complex. The antioxidantcapacity against superoxide and peroxyl radicals of VIVO(baic) resulted greater than for baicalin and correlated with previous results obtained for other VOflavonoid complexes. The coordination mode produces delocalization of the electron density and the stabilization of the radical formed by interactionwith external radicals.The complex and the ligand displayed no toxic (Artemia salina test) and no mutagenic (Ames test) effects.The complex improved the ability of the ligand to reduce cell viability of human lung cancer cell lines (A549) generating reactive oxygen species (ROS) in cells, being this effect reversed by pre-incubation of the cells with antioxidants such as vitamins C and E. The addition of NAC (N-acetyl-L-cysteine, a sequestering agent of free radicals)suppresses the anticancer effect, confirming the oxidative stress mechanism. The complex interactedwith bovine serum albumin (BSA) with stronger binding than baicalin and the mechanisms involved H bonding and van der Waals interactions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Oxidovanadium(Iv) Complex
dc.subject
Baicalin
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Antioxidant
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Anticancer
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Bsa Binding
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Antioxidant and anticancer effects and bioavailability studies of the flavonoid baicalin and its oxidovanadium(IV) complex
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-06-12T13:30:47Z
dc.journal.volume
166
dc.journal.pagination
150-161
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Martínez Medina, Juan José. Universidad Nacional del Chaco Austral; Argentina
dc.description.fil
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
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Fil: Pérez, Ana L.. Universidad Nacional del Litoral; Argentina
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Fil: Rizzi, Alberto Claudio. Universidad Nacional del Litoral; Argentina
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Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.journal.title
Journal of Inorganic Biochemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.jinorgbio.2016.11.005
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013416303762


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