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dc.contributor.author
Bonansea, Rocio Ines  
dc.contributor.author
Marino, Damian Jose Gabriel  
dc.contributor.author
Bertrand, Lidwina  
dc.contributor.author
Wunderlin, Daniel Alberto  
dc.contributor.author
Amé, María Valeria  
dc.date.available
2018-06-11T12:38:32Z  
dc.date.issued
2016-09  
dc.identifier.citation
Bonansea, Rocio Ines; Marino, Damian Jose Gabriel; Bertrand, Lidwina; Wunderlin, Daniel Alberto; Amé, María Valeria; Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (Jenynsia multidentata) exposed to these insecticides singly and in mixtures; Society of Environmental Toxicology and Chemistry; Environmental Toxicology and Chemistry; 36; 7; 9-2016; 1764-1774  
dc.identifier.issn
0730-7268  
dc.identifier.uri
http://hdl.handle.net/11336/48047  
dc.description.abstract
The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlorpyrifos; 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a technical mixture; and 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a mixture of commercial products. Fish exposed to cypermethrin accumulated this compound only in muscle, probably because of the low biotransformation capacity of this organ and the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of chlorpyrifos occurred in fish exposed to the insecticide (intestine > liver > gills) even when these fish had higher gluthatione-S-transferase (GST) activin gills and P-glycoprotein (P-gp) expression in the liver, compared with the control. Fish exposed to the technical mixture showed cypermethrin accumulation (liver > intestine > gills) with higher levels than those measured in fish after only cypermethrin exposure. Higher expression levels of CYP1A1 in the liver were also observed compared with the Control. Fish exposed to the commercial mixture accumulated both insecticides (cypermethrin: intestine > gills and chlorpyrifos: liver > intestine > gills > muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of cypermethrin and chlorpyrifos in J. multidentata, possibly associated with the biotransformation system inhibition.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Society of Environmental Toxicology and Chemistry  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
GAS CHROMATOGRAPHY ELECTRON CAPTURE DETECTOR  
dc.subject
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ELECTROSPRAY IONIZATION SOURCE QUADRUPOLE TIME-OF-FLIGHT ANALYZER  
dc.subject
METABOLISM  
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MIXTURES  
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TISSUE DISTRIBUTION  
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Meteorología y Ciencias Atmosféricas  
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Ciencias de la Tierra y relacionadas con el Medio Ambiente  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (Jenynsia multidentata) exposed to these insecticides singly and in mixtures  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-05-29T20:57:20Z  
dc.journal.volume
36  
dc.journal.number
7  
dc.journal.pagination
1764-1774  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Bonansea, Rocio Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina  
dc.description.fil
Fil: Marino, Damian Jose Gabriel. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones del Mar y la Atmósfera. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones del Mar y la Atmósfera; Argentina  
dc.description.fil
Fil: Bertrand, Lidwina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina  
dc.description.fil
Fil: Wunderlin, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina  
dc.description.fil
Fil: Amé, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina  
dc.journal.title
Environmental Toxicology and Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/etc.3613  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.3613