Artículo
Gaining acceptability for the Bayesian decision-theoretic approach in dose-escalation studies
Fecha de publicación:
07/2005
Editorial:
John Wiley & Sons Inc
Revista:
Pharmaceutical Statistics
ISSN:
1539-1604
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
There has recently been increasing demand for better designs to conduct first-into-man dose-escalation studies more efficiently, more accurately and more quickly. The authors look into the Bayesian decision-theoretic approach and use simulation as a tool to investigate the impact of compromises with conventional practice that might make the procedures more acceptable for implementation.
Palabras clave:
First Into Man
,
Optimal Design
,
Bayesian Decision
,
Dose Level
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Articulos(CCT - NORDESTE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - NORDESTE
Citación
Zhou, Yinghui; Lucini, María Magdalena; Gaining acceptability for the Bayesian decision-theoretic approach in dose-escalation studies; John Wiley & Sons Inc; Pharmaceutical Statistics; 4; 3; 7-2005; 161-171
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