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dc.contributor.author
Aguilera, Andrea Carolina
dc.contributor.author
Carvelli, Flavia Lorena
dc.contributor.author
Boschin, Veronica
dc.contributor.author
Mohamed, Fabian Heber
dc.contributor.author
Zyla, Leila Ester
dc.contributor.author
Sosa Escudero, Miguel Angel
dc.date.available
2018-04-12T18:44:47Z
dc.date.issued
2015-04
dc.identifier.citation
Aguilera, Andrea Carolina; Carvelli, Flavia Lorena; Boschin, Veronica; Mohamed, Fabian Heber; Zyla, Leila Ester; et al.; Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis; Csiro Publishing; Reproduction Fertility and Development; 28; 10; 4-2015; 1608-1617
dc.identifier.issn
1031-3613
dc.identifier.uri
http://hdl.handle.net/11336/41889
dc.description.abstract
One of the most striking features of the mammalian epididymis is the secretion of lysosomal enzymes (LE). These LE may play a role in sperm maturation. In the present study we investigated the activity and distribution of four LE (b-galactosidase (b-Gal), N-acetyl-b-D-glucosaminidase (b-NAG), a-mannosidase (a-Man) and b-glucuronidase) in bull epididymis at two different ages (6 months and 4 years) to determine whether these enzymes vary with sexual 5 maturity. In young, sexually immature (SI) bulls we found high LE activity in the epididymal tissue that accounts for a developed and active lysosomal apparatus. In contrast, low LE activity was measured in sexually mature (SM) bulls, and b-NAG and b-Gal were mostly secreted into the lumen. We also attempted to correlate LE distribution with the expression and functionality of mannose-6-phosphate receptors (MPRs), which are thought to be involved in proper delivery of LE to lysosomes. The cation-dependent MPR was highly expressed in SI bulls, with expression decreasing during adulthood, 10 whereas the expression of the cation-independent MPR was higher in SM than SI bulls. In addition, the four enzymes recovered from the epididymal lumen interact with both MPRs at each age. We conclude that the activity and distribution of LE in bull epididymis varies with sexual maturity and that the distribution is regulated differently by the two types of MPR. These findings could provide some molecular basis for male infertility.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Csiro Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Epididymis
dc.subject
Lysosomal Enzymes
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Mannose-6-Phosphate Receptors
dc.subject
Protein Secretion
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-27T13:35:26Z
dc.journal.volume
28
dc.journal.number
10
dc.journal.pagination
1608-1617
dc.journal.pais
Australia
dc.journal.ciudad
Collingwood
dc.description.fil
Fil: Aguilera, Andrea Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Carvelli, Flavia Lorena. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Boschin, Veronica. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Mohamed, Fabian Heber. Universidad Nacional de San Luis; Argentina
dc.description.fil
Fil: Zyla, Leila Ester. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Sosa Escudero, Miguel Angel. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.journal.title
Reproduction Fertility and Development
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1071/RD14380
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.publish.csiro.au/rd/RD14380
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