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dc.contributor.author
Miguelez Fernández, Anabel María Mercedes
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Burman, Ariel
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Martínez Cáceres, Alfredo I.
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Mininni, Camilo Juan
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Zanutto, Bonifacio Silvano
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Lew, Sergio Eduardo
dc.date.available
2018-04-09T18:51:27Z
dc.date.issued
2018-03
dc.identifier.citation
Miguelez Fernández, Anabel María Mercedes; Burman, Ariel; Martínez Cáceres, Alfredo I.; Mininni, Camilo Juan; Zanutto, Bonifacio Silvano; et al.; A spherical treadmill system to train head-fixed adult rats; Elsevier Science; Journal of Neuroscience Methods; 297; 3-2018; 22-30
dc.identifier.issn
0165-0270
dc.identifier.uri
http://hdl.handle.net/11336/41371
dc.description.abstract
Background While spherical treadmills are widely used in mouse models, there are only a few experimental setups suitable for adult rats, and none of them include head-fixation. New method We introduce a novel spherical treadmill apparatus for head-fixed rats that allows a wide repertory of natural responses. The rat is secured to a frame and placed on a freely rotating sphere. While being head-fixed, it can walk in any direction and perform different motor tasks. Comparison with existing methods Instead of being air-lifted, which is acceptable for light animals, the treadmill is sustained by three spherical bearings ensuring a smooth rotation in any direction. Movement detection is accomplished using a video camera that registers a dot pattern plotted on the sphere. Results Long Evans rats were trained to perform an auditory discrimination task in a Go/No-Go (walking/not-walking) paradigm. Animals were able to successfully discriminate between a 1 kHz and a 8 kHz auditory stimulus and execute the correct response, reaching the learning criterion (80% of correct responses) in approximately 20 training sessions. Conclusions Our system broadens the possibilities of head-fixation experiments in adult rats making them compatible with spatial navigation on a spherical treadmill.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Spherical Treadmill
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Auditory Discrimination
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Head-Fixation
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Ingeniería de Sistemas y Comunicaciones
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Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
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INGENIERÍAS Y TECNOLOGÍAS
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
A spherical treadmill system to train head-fixed adult rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-09T15:22:29Z
dc.journal.volume
297
dc.journal.pagination
22-30
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Miguelez Fernández, Anabel María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
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Fil: Burman, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
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Fil: Martínez Cáceres, Alfredo I.. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
dc.description.fil
Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Zanutto, Bonifacio Silvano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
dc.description.fil
Fil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
dc.journal.title
Journal of Neuroscience Methods
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jneumeth.2017.12.018
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165027017304363