Design of Peumus boldus tablets by direct compression using a novel dry plant extract

A solid pharmaceutical dosage formulation using a novel dry plant extract of Peumus boldus MOL. (Monimiaceae) (Pb) is proposed. The botanical evaluation of plant material, through morphological and anatomical diagnosis, is presented. This evaluation permits to identify the herb to be used correctly. The analysis of the most extractive solvent mixture and the attainment of plant extract (fluid and dry) are reported. Several formulations (tablets) containing a novel dry plant extract of Pb and common excipients for direct compression are evaluated. The following formulation: dry plant extract of Pb (170 mg), Avicel PH101 (112 mg), Lactose CD (112) and magnesium stearate (6 mg), compressed at 1000 mPa, showed the best pharmaceutical performance. © 2002 Elsevier Science B.V.

Palabras clave: Direct Compression , Dry Plant Extract , Peumus Boldus Mol. , Tablets

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/39176

URL: https://www.sciencedirect.com/science/article/pii/S0378517301009401

DOI: https://doi.org/10.1016/S0378-5173(01)00940-1

Colecciones

Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)

Citación

Palma, Santiago Daniel; Luján, María Claudia; Llabot, Juan Manuel; Barboza, Gloria Estela; Manzo, Ruben Hilario; et al.; Design of Peumus boldus tablets by direct compression using a novel dry plant extract; Elsevier Science; International Journal Of Pharmaceutics; 233; 1-2; 2-2002; 191-198

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