Mostrar el registro sencillo del ítem

dc.contributor.author
Carretero, M.  
dc.contributor.author
Escámez, M.J.  
dc.contributor.author
Prada, Federico  
dc.contributor.author
Mirones, I.  
dc.contributor.author
Garcia, M.  
dc.contributor.author
Holguín, A.  
dc.contributor.author
Duarte, B.  
dc.contributor.author
Podhajcer, Osvaldo Luis  
dc.contributor.author
Jorcano, J.L.  
dc.contributor.author
Larcher, F.  
dc.contributor.author
Del Rio, M.  
dc.date.available
2018-03-19T13:54:55Z  
dc.date.issued
2006-11  
dc.identifier.citation
Carretero, M.; Escámez, M.J.; Prada, Federico; Mirones, I.; Garcia, M.; et al.; Skin gene therapy for inherited and acquired disorders; Histology and Histopathology; Histology and Histopathology; 21; 11; 11-2006; 1233-1247  
dc.identifier.issn
1699-5848  
dc.identifier.uri
http://hdl.handle.net/11336/39167  
dc.description.abstract
The rapid advances associated with the Human Genome Project combined with the development of proteomics technology set the bases to face the challenge of human gene therapy. Different strategies must be evaluated based on the genetic defect to be corrected. Therefore, the re-expression of the normal counterpart should be sufficient to reverse phenotype in single-gene inherited disorders. A growing number of candidate diseases are being evaluated since the ADA deficiency was selected for the first approved human gene therapy trial (Blaese et al., 1995). To cite some of them: sickle cell anemia, hemophilia, inherited immune deficiencies, hyper-cholesterolemia and cystic fibrosis. The approach does not seem to be so straightforward when a polygenic disorder is going to be treated. Many human traits like diabetes, hypertension, inflammatory diseases and cancer, appear to be due to the combined action of several genes and environment. For instance, several wizard gene therapy strategies have recently been proposed for cancer treatment, including the stimulation of the immune system of the patient (Xue et al., 2005), the targeting of particular signalling pathways to selectively kill cancer cells (Westphal and Melchner, 2002) and the modulation of the interactions with the stroma and the vasculature (Liotta, 2001; Liotta and Kohn, 2001).  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Histology and Histopathology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Skin  
dc.subject
Gene  
dc.subject
Therapy  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Skin gene therapy for inherited and acquired disorders  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-03-15T15:21:46Z  
dc.identifier.eissn
0213-3911  
dc.journal.volume
21  
dc.journal.number
11  
dc.journal.pagination
1233-1247  
dc.journal.pais
España  
dc.journal.ciudad
Murcia  
dc.description.fil
Fil: Carretero, M.. CIEMAT; España  
dc.description.fil
Fil: Escámez, M.J.. CIEMAT; España  
dc.description.fil
Fil: Prada, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina  
dc.description.fil
Fil: Mirones, I.. CIEMAT; España  
dc.description.fil
Fil: Garcia, M.. CIEMAT; España  
dc.description.fil
Fil: Holguín, A.. CIEMAT; España  
dc.description.fil
Fil: Duarte, B.. CIEMAT; España  
dc.description.fil
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Jorcano, J.L.. CIEMAT; España  
dc.description.fil
Fil: Larcher, F.. CIEMAT; España  
dc.description.fil
Fil: Del Rio, M.. CIEMAT; España  
dc.journal.title
Histology and Histopathology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.hh.um.es/Abstracts/Vol_21/21_11/21_11_1233.htm  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.14670/HH-21.1233