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dc.contributor.author
Matturri, Luigi
dc.contributor.author
Cazzullo, Alessandra
dc.contributor.author
Turconi, Paola
dc.contributor.author
Roncoroni, Lucia
dc.contributor.author
Grana, Daniel Rodolfo
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dc.contributor.author
Milei, Jose
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dc.date.available
2018-03-16T18:01:06Z
dc.date.issued
2000-08
dc.identifier.citation
Matturri, Luigi; Cazzullo, Alessandra; Turconi, Paola; Roncoroni, Lucia; Grana, Daniel Rodolfo; et al.; Inflammatory cells, apoptosis and Chlamydia pneumoniae infection in atherosclerosis; Elsevier Ireland; International Journal of Cardiology; 75; 1; 8-2000; 23-33
dc.identifier.issn
0167-5273
dc.identifier.uri
http://hdl.handle.net/11336/39105
dc.description.abstract
Chlamydia pneumoniae (CP), chromosomal alterations and apoptosis were suggested as contributing factors in the pathogenesis of atherosclerosis. Early (EP) and unstable plaques (UP) were studied in order to assess infiltrate composition, the apoptotic index, chromosome 7 stability and to investigate the concurrent presence of CP in EP and UP. Paraffin embedded sections of three iliac arteries and four aortas from young donors (EP), and four coronaries and nine carotid arteries (UP) were used. Aside from histological techniques, immunophenotypification for macrophages, T and B cells, smooth muscle and endothelial cells; FISH and DNA nick end labeling were performed. The amplifications with PCR for CP infection were negative in all specimens. In the EP, a focal myointimal thickening with foam cells and scarce smooth muscle cells was observed. Macrophages were most frequent in the intima (10.8%) while T and B cells were found in 2.3 and 1.5%. In the UP a thin cap covering a lipid-rich core with widespread vascularization and with severe luminal obstruction was observed. Macrophages were increased (21%), and T (1.5%) and B cells (3.5%) in the caps and inner areas of the lipid cores. At these sites, the FISH showed trisomy and tetrasomy of chromosome 7 and apoptosis was very frequent (10-30%). Macrophages in intimal lesions is one of the most prominent, consistent and permanent features in EP, and an elevated apoptotic index and chromosome 7 instability might contribute to evolution from stable to complicated plaques, while CP seems to play no role. However, further studies are needed with more cases to confirm this last observation. Copyright (C) 2000 Elsevier Science Ireland Ltd.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Apoptosis
dc.subject
Atherosclerosis
dc.subject
Chlamydia Pneumoniae
dc.subject
Chromosome 7
dc.subject
Macrophage
dc.subject
Smooth Muscle Cell
dc.subject.classification
Medicina Critica y de Emergencia
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Inflammatory cells, apoptosis and Chlamydia pneumoniae infection in atherosclerosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-16T15:13:58Z
dc.journal.volume
75
dc.journal.number
1
dc.journal.pagination
23-33
dc.journal.pais
Irlanda
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dc.journal.ciudad
Shannon
dc.description.fil
Fil: Matturri, Luigi. Università degli Studi di Milano; Italia. IRCCS Ospedale Maggiore; Italia
dc.description.fil
Fil: Cazzullo, Alessandra. Università degli Studi di Milano; Italia. IRCCS Ospedale Maggiore; Italia
dc.description.fil
Fil: Turconi, Paola. IRCCS Ospedale Maggiore; Italia. Università degli Studi di Milano; Italia
dc.description.fil
Fil: Roncoroni, Lucia. IRCCS Ospedale Maggiore; Italia. Università degli Studi di Milano; Italia
dc.description.fil
Fil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad del Salvador. Facultad de Medicina; Argentina
dc.description.fil
Fil: Milei, Jose. Universidad del Salvador. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.journal.title
International Journal of Cardiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167527300003065
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S0167-5273(00)00306-5
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