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dc.contributor.author
Racca, María Agustina
dc.contributor.author
Novoa, Pablo Antonio
dc.contributor.author
Rodríguez, Iván
dc.contributor.author
Della Vedova, Ana Belen
dc.contributor.author
Pellizas, Claudia Gabriela
dc.contributor.author
Demarchi, Marcela
dc.contributor.author
Donadio, Ana Carolina
dc.date.available
2018-03-06T18:10:31Z
dc.date.issued
2015-01
dc.identifier.citation
Racca, María Agustina; Novoa, Pablo Antonio; Rodríguez, Iván; Della Vedova, Ana Belen; Pellizas, Claudia Gabriela; et al.; Renal dysfunction and intragraft proMMP9 activity in renal transplant recipients with interstitial fibrosis and tubular atrophy; Wiley Blackwell Publishing, Inc; Transplant International; 28; 1; 1-2015; 71-78
dc.identifier.issn
0934-0874
dc.identifier.uri
http://hdl.handle.net/11336/37966
dc.description.abstract
Chronic renal allograft injury is reflected by interstitial fibrosis and tubular atrophy (IF/TA) and by the accumulation of extracellular matrix (ECM). Metalloproteinases (MMPs) are renal physiologic regulators of ECM degradation. Changes in MMPs expression or activity may disturb ECM turnover leading to glomerular scarring and worsening renal function. Our goal was to investigate intragraft MMP2 and MMP9 activities and their correlation with renal dysfunction. Plasma MMP2 and MMP9 activities were analyzed as noninvasive markers of renal allograft deterioration. Transplanted patients were biopsied and histopathologically characterized as IF/TA+ or IF/TA-. Renal function was evaluated by serum creatinine, glomerular filtration rate (GFR) estimated by Modification of Diet in Renal Disease equation and urinary protein/creatinine ratio. Kidney and plasma MMP2 and MMP9 activities were analyzed by zymography. A significant renal dysfunction was observed in IF/TA+ patients. Intragraft proMMP9 showed a significant higher activity in IF/TA+ than in IF/TA- samples and was inversely correlated with the GFR. Intragraft proMMP2 activity tended to increase in IF/TA+ samples, although no statistic significance was reached. Circulating proMMP2 and proMMP9 activities did not show significant differences between groups. Our data provide evidence that correlates intragraft proMMP9 activity with the fibrotic changes and renal dysfunction observed in IF/TA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Chronic Allograft Nephropathy
dc.subject
Interstitial Fibrosis And Tubular Atrophy
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Kidney Transplantation
dc.subject
Metalloproteinases
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Renal Dysfunction
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Renal dysfunction and intragraft proMMP9 activity in renal transplant recipients with interstitial fibrosis and tubular atrophy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-02T14:00:57Z
dc.journal.volume
28
dc.journal.number
1
dc.journal.pagination
71-78
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Racca, María Agustina. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil
Fil: Novoa, Pablo Antonio. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil
Fil: Rodríguez, Iván. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil
Fil: Della Vedova, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Pellizas, Claudia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Demarchi, Marcela. Universidad Nacional de Córdoba. Facultad de Medicina. Hospital Córdoba; Argentina
dc.description.fil
Fil: Donadio, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.journal.title
Transplant International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/tri.12445
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/tri.12445/abstract
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